Walker G B, Harrison P V, Seville R H, Smith J F
Beaumont Hospital, Lancaster, U.K.
Br J Dermatol. 1989 Feb;120(2):277-83. doi: 10.1111/j.1365-2133.1989.tb07793.x.
In a single blind trial, 16 in-patients with psoriasis were treated with short contact dithranol in stiff Lassar's paste and in a stiff emulsifying ointment base of equivalent stiffness. The preparations were equally effective in clearing psoriasis and well tolerated. Perilesional treatment burns, reported with soft ointments, were not seen with the stiff emulsifying ointment preparation. Furthermore, unlike the paste, excess stiff emulsifying ointment can be removed by simply wiping with a moistened cloth, thus greatly facilitating home management of psoriasis.
在一项单盲试验中,16名银屑病住院患者接受了短程接触地蒽酚治疗,药物分别制成硬的拉萨尔糊剂和同等硬度的硬乳化软膏基质。两种制剂在清除银屑病方面同样有效,且耐受性良好。用软膏时曾有报道出现的皮损周围治疗灼伤,在硬乳化软膏制剂中未出现。此外,与糊剂不同,多余的硬乳化软膏只需用湿布擦拭即可去除,从而极大地方便了银屑病的家庭护理。