Göransson A
Acta Derm Venereol. 1987;67(2):149-53.
Thirty psoriatic out-patients were treated as a right-left comparison with dithranol (0.1, 0.5, 1, 2%) and butantrone (0.66, 1.3, 2.7, 3.9%) short contact therapy, both in white petrolatum. Fifteen of the treated patients cleared well and no obvious differences between the treated sides were clinically observed. Six patients showed some improvement, but in four of them the dithranol treated side cleared sooner and the therapy was continued with dithranol short contact therapy on both sides. In two patients the thick lesions cleared slowly and the therapy was continued with dithranol in Lassar's paste. The treatment was discontinued in nine patients: in five patients because short contact therapy was ineffective and in one patient because of strong skin irritation on both treated sides. In three patients the treatment was discontinued for non-medical reasons. Butantrone has an antipsoriatic activity almost equal to that of dithranol. When short contact treatment is used, erythema and staining with butantrone are weaker than with dithranol. Because the short contact tolerability of butantrone was good, it might be possible to start with higher concentrations.
30名银屑病门诊患者接受了一项左右对比治疗，分别使用白凡士林基质的地蒽酚（0.1%、0.5%、1%、2%）和丁酮蒽酚（0.66%、1.3%、2.7%、3.9%）进行短程接触疗法。15名接受治疗的患者病情明显好转，两侧治疗效果在临床上未观察到明显差异。6名患者有一定改善，但其中4名患者地蒽酚治疗侧起效更快，遂继续双侧使用地蒽酚短程接触疗法。2名患者厚皮损消退缓慢，遂继续使用含地蒽酚的拉萨尔糊剂进行治疗。9名患者停止治疗：5名患者因短程接触疗法无效，1名患者因双侧治疗部位出现强烈皮肤刺激，3名患者因非医学原因停止治疗。丁酮蒽酚的抗银屑病活性几乎与地蒽酚相当。使用短程接触疗法时，丁酮蒽酚引起的红斑和染色比地蒽酚轻。由于丁酮蒽酚的短程接触耐受性良好，或许可以从更高浓度开始使用。
