Maeda Koji, Ohki Takao, Kanaoka Yuji, Toya Naoki, Baba Takeshi, Hara Masayuki, Hagiwara Shin
Division of Vascular Surgery, Department of Surgery, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Surg Today. 2016 Aug;46(8):985-94. doi: 10.1007/s00595-015-1262-8. Epub 2015 Oct 15.
The management of abdominal aortic aneurysm (AAA) with concomitant malignancy is controversial in terms of which treatment should come first. The aim of this study was to evaluate the outcomes of endovascular aortic repair (EVAR) as the initial treatment prior to the treatment of malignancy for patients with AAA and concomitant malignancy.
EVAR for AAA was performed in 1,175 cases between April 2007 and April 2014, of which 63 patients (5.4 %) who had AAAs and malignancy were identified. The clinical details and outcomes for patients with AAA and malignancy were evaluated.
The mean age of patients with AAA and malignancy was 76.6 years. Thirty-three patients underwent EVAR before surgery for their malignancies, and 30 patients received chemoradiotherapy following EVAR. No significant differences in the length of stay (LOS), 30-day mortality, and morbidities were observed in all groups. However, the overall survival rate of the patients who had AAA and malignancy was lower than those who had only AAA (P < 0.0001). The mean intervals from EVAR to surgery and chemoradiotherapy for malignancy in our institution were 13.4 days (overall 38.1 days) and 5.8 days (overall 18.2 days), respectively.
EVAR for patients with AAA and concomitant malignancy may be acceptable in terms of a short LOS and resulting in treatment for malignancy without delay.
腹主动脉瘤(AAA)合并恶性肿瘤的治疗顺序存在争议。本研究旨在评估对于AAA合并恶性肿瘤患者,将血管腔内主动脉修复术(EVAR)作为恶性肿瘤治疗前的初始治疗的效果。
2007年4月至2014年4月间,1175例患者接受了AAA的EVAR治疗,其中63例(5.4%)患者合并AAA和恶性肿瘤。对这些患者的临床细节和治疗效果进行了评估。
AAA合并恶性肿瘤患者的平均年龄为76.6岁。33例患者在恶性肿瘤手术前接受了EVAR治疗,30例患者在EVAR后接受了放化疗。所有组在住院时间(LOS)、30天死亡率和并发症方面均未观察到显著差异。然而,AAA合并恶性肿瘤患者的总生存率低于仅患有AAA的患者(P < 0.0001)。在本机构中,从EVAR到恶性肿瘤手术和放化疗的平均间隔时间分别为13.4天(总计38.1天)和5.8天(总计18.2天)。
对于AAA合并恶性肿瘤患者,EVAR在住院时间短且能及时进行恶性肿瘤治疗方面可能是可接受的。