Courtois P, Labbé M, Pourtois M, Mandelbaum I M
Bull Group Int Rech Sci Stomatol Odontol. 1989 Jan;32(1):19-22.
Pathogeny of adult chronic periodontitis is still unclear. Bacteriological and chemical analysis of crevicular fluid have shown, in active sites of the disease, a simultaneous presence of anaerobes and their major by-product: short-chain fatty acids. The last can decrease "in vitro" the neutrophil intracellular pH, whenever these cells are incubated in an acid medium. Clinical investigations are scarce which hold out data useful to attempt verifying this possible physiopathological mechanism. This work shows the presence of anaerobes in the active periodontal pockets, together with the presence of short-chain fatty acids likely to reach a concentration level comparable to that used for inhibiting neutrophils "in vitro". Forthcoming studies should investigate about a possible intracellular pH drop in the neutrophils and other cells of the inflamed periodontium.
成人慢性牙周炎的发病机制仍不明确。龈沟液的细菌学和化学分析表明，在该疾病的活动部位，厌氧菌及其主要副产物——短链脂肪酸同时存在。只要将中性粒细胞置于酸性培养基中培养，短链脂肪酸就能在“体外”降低其细胞内pH值。目前临床研究较少，缺乏有助于验证这一可能的生理病理机制的数据。这项研究表明，在活动期牙周袋中存在厌氧菌，同时存在的短链脂肪酸浓度可能达到“体外”抑制中性粒细胞时的水平。后续研究应探讨炎症牙周组织中的中性粒细胞及其他细胞的细胞内pH值是否可能下降。
