从中国南方广西一只家鸭中分离出的H3N6禽流感病毒全基因组序列的特征分析
Characterization of the Whole-Genome Sequence of an H3N6 Avian Influenza Virus, Isolated from a Domestic Duck in Guangxi, Southern China.
作者信息
Liu Tingting, Xie Zhixun, Luo Sisi, Xie Liji, Deng Xianwen, Xie Zhiqing, Huang Li, Huang Jiaoling, Zhang Yanfang, Zeng Tingting, Wang Sheng
机构信息
College of Life Science, Guangxi Normal University, Guilin, Guangxi Province, China.
Guangxi Key Laboratory of Animal Vaccines and Diagnostics, Guangxi Veterinary Research Institute, Nanning, Guangxi Province, China
出版信息
Genome Announc. 2015 Oct 15;3(5):e01190-15. doi: 10.1128/genomeA.01190-15.
A field strain of H3N6 avian influenza virus (AIV), A/duck/Guangxi/175D12/2014(H3N6), was isolated from a native duck in Guangxi Province, southern China, in 2014. All of the eight AIV gene segments were sequenced, and sequence results revealed that there were 11 amino acid deletions at the NA stalk region. The NA, PB2, and NP genes showed highest homology to H5N6 AIV, and the PA gene showed highest homology to H7N2 AIV. Phylogenetic analysis indicated that the eight AIV gene segments belonged to the Eurasian lineage. These findings provide scientific evidence of possible or potential mutations of H3N6 AIV circulating in waterfowl in southern China.
2014年，一株H3N6禽流感病毒（AIV）野外毒株A/duck/Guangxi/175D12/2014（H3N6）从中国南方广西省的一只本地鸭中分离出来。对所有8个AIV基因片段进行了测序，序列结果显示在NA茎区有11个氨基酸缺失。NA、PB2和NP基因与H5N6 AIV的同源性最高，PA基因与H7N2 AIV的同源性最高。系统发育分析表明，这8个AIV基因片段属于欧亚谱系。这些发现为中国南方水禽中传播的H3N6 AIV可能或潜在的突变提供了科学证据。
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