来自韩国一所高中疫情暴发的属于北京家族的结核分枝杆菌K的全基因组序列。
Complete genome sequence of Mycobacterium tuberculosis K from a Korean high school outbreak, belonging to the Beijing family.
作者信息
Han Seung Jung, Song Taeksun, Cho Yong-Joon, Kim Jong-Seok, Choi Soo Young, Bang Hye-Eun, Chun Jongsik, Bai Gill-Han, Cho Sang-Nae, Shin Sung Jae
机构信息
Department of Microbiology, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea.
出版信息
Stand Genomic Sci. 2015 Oct 14;10:78. doi: 10.1186/s40793-015-0071-4. eCollection 2015.
Mycobacterium tuberculosis K, a member of the Beijing family, was first identified in 1999 as the most prevalent genotype in South Korea among clinical isolates of M. tuberculosis from high school outbreaks. M. tuberculosis K is an aerobic, non-motile, Gram-positive, and non-spore-forming rod-shaped bacillus. A transmission electron microscopy analysis displayed an abundance of lipid bodies in the cytosol. The genome of the M. tuberculosis K strain was sequenced using two independent sequencing methods (Sanger and Illumina). Here, we present the genomic features of the 4,385,518-bp-long complete genome sequence of M. tuberculosis K (one chromosome, no plasmid, and 65.59 % G + C content) and its annotation, which consists of 4194 genes (3447 genes with predicted functions), 48 RNA genes (3 rRNA and 45 tRNA) and 261 genes with peptide signals.
结核分枝杆菌K属于北京家族，1999年首次被鉴定为韩国高中结核病暴发临床分离株中最常见的基因型。结核分枝杆菌K是一种需氧、无运动性、革兰氏阳性、不形成芽孢的杆状杆菌。透射电子显微镜分析显示胞质溶胶中有大量脂质体。采用两种独立的测序方法（桑格测序法和Illumina测序法）对结核分枝杆菌K菌株的基因组进行了测序。在此，我们展示了结核分枝杆菌K的4385518bp长的完整基因组序列（一条染色体，无质粒，G+C含量为65.59%）的基因组特征及其注释，该基因组由4194个基因（3447个具有预测功能的基因）、48个RNA基因（3个rRNA和45个tRNA）和261个具有肽信号的基因组成。
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