Ungprasert Patompong, Wijarnpreecha Karn, Thongprayoon Charat
aDepartment of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota bDepartment of Medicine, Bassett Medical Center, Cooperstown, New York, USA cDepartment of Medicine, Division of Rheumatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Eur J Gastroenterol Hepatol. 2016 Jan;28(1):90-4. doi: 10.1097/MEG.0000000000000493.
Dyslipidemia is common among patients with primary biliary cirrhosis (PBC) and might increase the risk of cerebrovascular accident (CVA). However, data from epidemiologic studies remain inconclusive. This study aims to further investigate this association.
We carried out a systematic review and meta-analysis of observational studies that compared the risk of CVA in patients with PBC versus controls. Pooled risk ratios and 95% confidence intervals were combined using a random-effect, generic inverse variance method of DerSimonian and Laird.
Four studies with 2309 patients with PBC were identified and included in our data analysis. The pooled risk ratio of CVA in patients with PBC was 1.11 (95% confidence interval, 0.81-1.51). The statistical heterogeneity was insignificant, with an I of 14%.
A significantly increased risk of CVA among patients with PBC was not observed in this study.
血脂异常在原发性胆汁性肝硬化（PBC）患者中很常见，可能会增加脑血管意外（CVA）的风险。然而，流行病学研究的数据仍无定论。本研究旨在进一步调查这种关联。
我们对观察性研究进行了系统评价和荟萃分析，比较了PBC患者与对照组发生CVA的风险。采用DerSimonian和Laird的随机效应、通用逆方差法合并汇总风险比和95%置信区间。
共纳入4项研究，涉及2309例PBC患者，并纳入我们的数据分析。PBC患者发生CVA的汇总风险比为1.11（95%置信区间，0.81-1.51）。统计异质性不显著，I²为14%。
本研究未观察到PBC患者发生CVA的风险显著增加。
