Zayats Tetyana, Johansson Stefan, Haavik Jan
Department of Biomedicine, K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
Department of Clinical Science, K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
Behav Brain Funct. 2015 Oct 16;11(1):33. doi: 10.1186/s12993-015-0078-4.
Genome-wide association (GWA) studies have shown that many different genetic variants cumulatively contribute to the risk of psychiatric disorders. It has also been demonstrated that various parent-of-origin effects (POE) may differentially influence the risk of these disorders. Together, these observations have provided important new possibilities to uncover the genetic underpinnings of such complex phenotypes. As POE so far have received little attention in neuropsychiatric disorders, there is still much progress to be made. Here, we mainly focus on the new and emerging role of POE in attention-deficit hyperactivity disorder (ADHD). We review the current evidence that POE play an imperative role in vulnerability to ADHD and related disorders. We also discuss how POE can be assessed using statistical genetics tools, expanding the resources of modern psychiatric genetics. We propose that better comprehension and inspection of POE may offer new insight into the molecular basis of ADHD and related phenotypes, as well as the potential for preventive and therapeutic interventions.
全基因组关联（GWA）研究表明，许多不同的基因变异会累积增加患精神疾病的风险。研究还表明，各种源自父母的效应（POE）可能会对这些疾病的风险产生不同影响。这些观察结果共同为揭示此类复杂表型的遗传基础提供了重要的新可能性。由于到目前为止POE在神经精神疾病中很少受到关注，因此仍有很大的进展空间。在这里，我们主要关注POE在注意力缺陷多动障碍（ADHD）中的新出现的作用。我们回顾了当前的证据，即POE在ADHD及相关疾病的易感性中起着至关重要的作用。我们还讨论了如何使用统计遗传学工具评估POE，从而扩展现代精神遗传学的资源。我们提出，更好地理解和研究POE可能会为ADHD及相关表型的分子基础以及预防和治疗干预的潜力提供新的见解。
