Phirtskhalaishvili Tamar, Bayer Florian, Edet Stephane, Bongiovanni Isabelle, Hogan Julien, Couchoud Cécile
REIN registry, Agence de la biomédecine, France Children's Medical Centre "Mrcheveli," Tbilissi, Georgia.
REIN registry, Agence de la biomédecine, France.
Perit Dial Int. 2016 May-Jun;36(3):326-33. doi: 10.3747/pdi.2015.00003. Epub 2015 Oct 16.
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Health-care systems must attempt to provide appropriate, high-quality, and economically sustainable care that meets the needs and choices of patients with end-stage renal disease (ESRD). France offers 9 different modalities of dialysis, each characterized by dialysis technique, the extent of professional assistance, and the treatment site. The aim of this study was 1) to describe the various dialysis modalities in France and the patient characteristics associated with each of them, and 2) to analyze their regional patterns to identify possible unexpected associations between case-mixes and dialysis modalities. ♦
The clinical characteristics of the 37,421 adult patients treated by dialysis were described according to their treatment modality. Agglomerative hierarchical cluster analysis was used to aggregate the regions into clusters according to their use of these modalities and the characteristics of their patients. ♦
The gradient of patient characteristics was similar from home hemodialyis (HD) to in-center HD and from non-assisted automated peritoneal dialysis (APD) to assisted continuous ambulatory peritoneal dialysis (CAPD). Analyzing their spatial distribution, we found differences in the patient case-mix on dialysis across regions but also differences in the health-care provided for them. The classification of the regions into 6 different clusters allowed us to detect some unexpected associations between case-mixes and treatment modalities. ♦
The 9 modalities of treatment available make it theoretically possible to adapt treatment to patients' clinical characteristics and abilities. However, although we found an overall appropriate association of dialysis modalities to the case-mix, major inter-region heterogeneity and the low rate of peritoneal dialysis (PD) and home HD suggest that factors besides patients' clinical conditions impact the choice of dialysis modality. The French organization should now be evaluated in terms of patients' quality of life, satisfaction, survival, and global efficiency.
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医疗保健系统必须努力提供适当、高质量且经济上可持续的护理,以满足终末期肾病(ESRD)患者的需求和选择。法国提供9种不同的透析方式,每种方式的特点在于透析技术、专业协助程度和治疗地点。本研究的目的是:1)描述法国的各种透析方式以及与之相关的患者特征;2)分析其区域模式,以识别病例组合与透析方式之间可能存在的意外关联。♦
根据透析治疗方式描述了37421例成年透析患者的临床特征。采用凝聚层次聚类分析,根据各地区对这些透析方式的使用情况及其患者特征将各地区聚为不同的类别。♦
从家庭血液透析(HD)到中心血液透析,以及从非辅助自动腹膜透析(APD)到辅助持续性非卧床腹膜透析(CAPD),患者特征的梯度相似。分析其空间分布时,我们发现各地区透析患者的病例组合存在差异,同时为他们提供的医疗保健也存在差异。将各地区分为6个不同的类别,使我们能够检测到病例组合与治疗方式之间一些意外的关联。♦
现有的9种治疗方式理论上使治疗能够适应患者的临床特征和能力。然而,尽管我们发现透析方式与病例组合总体上有适当的关联,但地区间存在较大异质性,且腹膜透析(PD)和家庭血液透析的比例较低,这表明除患者临床状况外,还有其他因素影响透析方式的选择。现在应该从患者的生活质量、满意度、生存率和整体效率方面对法国的这种组织安排进行评估。