Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Physiology (Bethesda). 2023 Sep 1;38(5):0. doi: 10.1152/physiol.00004.2023. Epub 2023 Apr 4.
Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure and a significant public health concern for which limited effective therapies exist. Inflammation triggered by comorbidity burden is a critical element of HFpEF pathophysiology. Here, we discuss evidence for comorbidity-driven systemic and myocardial inflammation and the mechanistic role of inflammation in pathological myocardial remodeling in HFpEF.
射血分数保留的心力衰竭（HFpEF）现在是心力衰竭最常见的形式，也是一个存在有限有效治疗方法的重大公共卫生问题。由合并症负担引发的炎症是 HFpEF 病理生理学的一个关键因素。在这里，我们讨论了合并症驱动的全身性和心肌炎症的证据，以及炎症在 HFpEF 病理性心肌重构中的机制作用。
