经间歇性θ波爆发刺激（iTBS）调节的虚拟现实挑战对包括蜘蛛恐惧症患者在内的参与者的心理生理影响。
Psychophysiological effects of an iTBS modulated virtual reality challenge including participants with spider phobia.
作者信息
Notzon S, Deppermann S, Fallgatter A, Diemer J, Kroczek A, Domschke K, Zwanzger P, Ehlis A-C
机构信息
Mood and Anxiety Disorders Research Unit, Department of Psychiatry, University of Muenster, Albert-Schweitzer-Campus 1, Gebaeude A9, 48149 Muenster, Germany.
Department of Psychiatry and Psychotherapy, Calwerstr. 14, University of Tuebingen, 72076 Tuebingen, Germany.
出版信息
Biol Psychol. 2015 Dec;112:66-76. doi: 10.1016/j.biopsycho.2015.10.003. Epub 2015 Oct 22.
Preliminary evidence suggests beneficial effects of transcranial magnetic stimulation (TMS) on anxiety. The objective of this study was to investigate the effects of intermittent theta burst stimulation (iTBS) as a form of TMS on acute anxiety provoked by a virtual reality (VR) scenario. Participants with spider phobia (n=41) and healthy controls (n=42) were exposed to a spider scenario in VR after one session of iTBS over the prefrontal cortex or sham treatment. Participants with spider phobia reacted with more anxiety compared to healthy controls. Their heart rate and skin conductance increased compared to baseline. Contrary to expectations, iTBS did not influence these reactions, but modulated heart rate variability (HRV). Sympathetic influence on HRV showed an increase in the active iTBS group only. This study does not support the idea of beneficial effects of a single session of iTBS on anxiety, although other protocols or repeated sessions might be effective.
初步证据表明经颅磁刺激（TMS）对焦虑有有益影响。本研究的目的是调查间歇性theta爆发刺激（iTBS）作为TMS的一种形式对虚拟现实（VR）场景引发的急性焦虑的影响。蜘蛛恐惧症患者（n = 41）和健康对照组（n = 42）在对前额叶皮层进行一次iTBS治疗或假治疗后，在VR中接触蜘蛛场景。与健康对照组相比，蜘蛛恐惧症患者的焦虑反应更强。与基线相比，他们的心率和皮肤电导率增加。与预期相反，iTBS并未影响这些反应，但调节了心率变异性（HRV）。仅在主动iTBS组中，交感神经对HRV的影响有所增加。本研究不支持单次iTBS对焦虑有有益影响的观点，尽管其他方案或重复治疗可能有效。
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