间充质干细胞在肝脏修复中的治疗潜力。

The Therapeutic Promise of Mesenchymal Stem Cells for Liver Restoration.

机构信息

Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.

出版信息

Trends Mol Med. 2015 Nov;21(11):673-686. doi: 10.1016/j.molmed.2015.09.004. Epub 2015 Oct 22.

DOI:10.1016/j.molmed.2015.09.004

PMID:26476857

Abstract

Hepatocyte transplantation aims to provide a functional substitution of liver tissue lost due to trauma or toxins. Chronic liver diseases are associated with inflammation, deterioration of tissue homeostasis, and deprivation of metabolic capacity. Recent advances in liver biology have focused on the pro-regenerative features of mesenchymal stem cells (MSCs). We argue that MSCs represent an attractive therapeutic option to treat liver disease. Indeed, their pleiotropic actions include the modulation of immune reactions, the stimulation of cell proliferation, and the attenuation of cell death responses. These characteristics are highly warranted add-ons to their capacity for hepatocyte differentiation. Undoubtedly, the elucidation of the regenerative mechanisms of MSCs in different liver diseases will promote their versatile and disease-specific therapeutic use.

摘要

肝细胞移植旨在为因创伤或毒素而丧失的肝组织提供功能替代。慢性肝脏疾病与炎症、组织内稳态恶化和代谢能力丧失有关。肝脏生物学的最新进展集中在间充质干细胞（MSCs）的促再生特性上。我们认为 MSC 是治疗肝脏疾病的一种有吸引力的治疗选择。事实上，它们的多效作用包括调节免疫反应、刺激细胞增殖和减轻细胞死亡反应。这些特性是其肝细胞分化能力的重要补充。毫无疑问，阐明 MSCs 在不同肝脏疾病中的再生机制将促进其在多种疾病中的广泛应用和针对特定疾病的治疗。