Hou Jinliang, Xiang Jianguo, Li Deliang, Liu Xinhua, Pan Wangcheng
College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
Changde Dabeinong Feed Co. Ltd., Changde, China.
Front Nutr. 2022 Nov 7;9:1019430. doi: 10.3389/fnut.2022.1019430. eCollection 2022.
A large number of studies have proved that biological metabolic phenotypes exist objectively and are gradually recognized by humans. Gut microbes affect the host's metabolic phenotype. They directly or indirectly participate in host metabolism, physiology and immunity through changes in population structure, metabolite differences, signal transduction and gene expression. Obtaining comprehensive information and specific identification factors associated with gut microbiota and host metabolic phenotypes has become the focus of research in the field of gut microbes, and it has become possible to find new and effective ways to prevent or treat host metabolic diseases. In the future, precise treatment of gut microbes will become one of the new therapeutic strategies. This article reviews the content of gut microbes and carbohydrate, amino acid, lipid and nucleic acid metabolic phenotypes, including metabolic intermediates, mechanisms of action, latest research findings and treatment strategies, which will help to understand the relationship between gut microbes and host metabolic phenotypes and the current research status.
大量研究证明，生物代谢表型客观存在，并逐渐被人类所认识。肠道微生物影响宿主的代谢表型。它们通过种群结构变化、代谢物差异、信号转导和基因表达直接或间接参与宿主代谢、生理和免疫。获取与肠道微生物群和宿主代谢表型相关的全面信息和特异性识别因子已成为肠道微生物领域的研究重点，并且找到预防或治疗宿主代谢疾病的新的有效方法已成为可能。未来，对肠道微生物的精准治疗将成为新的治疗策略之一。本文综述了肠道微生物与碳水化合物、氨基酸、脂质和核酸代谢表型的内容，包括代谢中间体、作用机制、最新研究发现和治疗策略，这将有助于了解肠道微生物与宿主代谢表型之间的关系以及当前的研究现状。
