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基于活细胞的药物输送系统的理论基础、现状和挑战。

Theoretical basis, state and challenges of living cell-based drug delivery systems.

机构信息

Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

出版信息

Theranostics. 2024 Aug 19;14(13):5152-5183. doi: 10.7150/thno.99257. eCollection 2024.

DOI:10.7150/thno.99257
PMID:39267776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11388066/
Abstract

The therapeutic efficacy of drugs is determined, to a certain extent, by the efficiency of drug delivery. The low efficiency of drug delivery systems (DDSs) is frequently associated with serious toxic side effects and can even prove fatal in certain cases. With the rapid development of technology, drug delivery has evolved from using traditional frameworks to using nano DDSs (NDDSs), endogenous biomaterials DDSs (EBDDSs), and living cell DDSs (LCDDSs). LCDDSs are receiving widespread attention from researchers at present owing to the unique advantages of living cells in targeted drug delivery, including their excellent biocompatibility properties, low immunogenicity, unique biological properties and functions, and role in the treatment of diseases. However, the theoretical basis and techniques involved in the application of LCDDSs have not been extensively summarized to date. Therefore, this review comprehensively summarizes the properties and applications of living cells, elaborates the various drug loading approaches and controlled drug release, and discusses the results of clinical trials. The review also discusses the current shortcomings and prospects for the future development of LCDDSs, which will serve as highly valuable insights for the development and clinical transformation of LCDDSs in the future.

摘要

药物的治疗效果在一定程度上取决于药物输送的效率。药物输送系统（DDS）的效率低下常常与严重的毒副作用有关，在某些情况下甚至可能致命。随着技术的快速发展，药物输送已经从使用传统的框架发展到使用纳米 DDS（NDDS）、内源性生物材料 DDS（EBDDS）和活细胞 DDS（LCDDS）。由于活细胞在靶向药物输送方面具有独特的优势，包括其出色的生物相容性、低免疫原性、独特的生物学特性和功能以及在疾病治疗中的作用，LCDDS 目前受到研究人员的广泛关注。然而，迄今为止，尚未广泛总结 LCDDS 应用所涉及的理论基础和技术。因此，本综述全面总结了活细胞的特性和应用，详细阐述了各种药物负载方法和控制药物释放，并讨论了临床试验的结果。该综述还讨论了 LCDDS 目前的缺点和未来发展前景，这将为未来 LCDDS 的开发和临床转化提供非常有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0d/11388066/ff64b5af68c4/thnov14p5152g010.jpg
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