具有抗脂质作用的草药及其与作为化学抗高脂血症类药物的他汀类药物的相互作用：一项系统综述。
Herbs with anti-lipid effects and their interactions with statins as a chemical anti- hyperlipidemia group drugs: A systematic review.
作者信息
Rouhi-Boroujeni Hojjat, Rouhi-Boroujeni Hamid, Heidarian Esfandiar, Mohammadizadeh Fereshteh, Rafieian-Kopaei Mahmoud
机构信息
Member of Student Research Committee, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Clinical Biochemistry Research Center AND Department of Pulmonology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
出版信息
ARYA Atheroscler. 2015 Jul;11(4):244-51.
BACKGROUND
The present systematic review aimed to express the clinical anti-lipid effects of different types of herbs, as well as described studied interactions between herbal remedies and prescribed drugs for hyperlipidemic patients which were based on in vitro experiments, animal studies, and empirical clinical experiences.
METHODS
For this systematic review, we explored 2183 published papers about herbal drugs interactions from November 1967 to August 2014, fulfilling eligibility criteria by searching in some databases such as Web of Science, Medline, Scopus, Embase, Cinahl, and the Cochrane database. The main keywords used for searching included: herbal medicine, herbs, statin, lipid, and herb-drug interaction.
RESULTS
Among published articles about herb-drug interactions, 185 papers met the initial search criteria and among them, 92 papers were potentially retrievable including a description of 17 herbs and medicinal plants. In first step and by reviewing all published manuscripts on beneficial effects of herbs on serum lipids level, 17 herbs were described to be effective on lipid profile as lowering serum triglyceride, total cholesterol, low-density lipoprotein cholesterol as well as increasing serum high-density lipoprotein level. Some herbs such as celery could even affect the hepatic triglyceride concentrations. The herbal reaction toward different types of statins is varied so that grapefruit or pomegranate was interacted with only some types of statins, but not with all statin types. In this context, administration of herbal materials can lead to decreased absorption of statins or decreased the plasma concentration of these drugs.
CONCLUSION
Various types of herbs can potentially reduce serum lipid profile with the different pathways; however, the herb-drug interactions may decrease pharmacological therapeutic effects of anti-hyperlipidemic drugs that should be considered when approved herbs are prescribed.
背景
本系统评价旨在阐述不同类型草药的临床抗脂质作用，并描述基于体外实验、动物研究和临床经验的草药疗法与高脂血症患者处方药之间的相互作用。
方法
对于本系统评价，我们检索了1967年11月至2014年8月期间发表的2183篇关于草药药物相互作用的论文，通过在科学网、医学期刊数据库、Scopus、Embase、护理学与健康领域数据库及Cochrane数据库等一些数据库中搜索来满足纳入标准。搜索使用的主要关键词包括：草药医学、草药、他汀类药物、脂质、草药 - 药物相互作用。
结果
在已发表的关于草药 - 药物相互作用的文章中，185篇论文符合初步检索标准，其中92篇论文可能可检索到，包括对17种草药和药用植物的描述。第一步，通过回顾所有已发表的关于草药对血脂水平有益作用的手稿，描述了17种草药对脂质谱有效，可降低血清甘油三酯、总胆固醇、低密度脂蛋白胆固醇以及提高血清高密度脂蛋白水平。一些草药如芹菜甚至可以影响肝脏甘油三酯浓度。草药对不同类型他汀类药物的反应各不相同，例如葡萄柚或石榴仅与某些类型的他汀类药物相互作用，而非与所有他汀类药物相互作用。在这种情况下，使用草药材料可能会导致他汀类药物吸收减少或这些药物的血浆浓度降低。
结论
各种类型的草药可能通过不同途径潜在地降低血脂谱；然而，草药 - 药物相互作用可能会降低抗高脂血症药物的药理治疗效果，在开具经批准的草药处方时应予以考虑。
Zotero 插件