孕期使用降脂草药：安全性与剂量的系统评价

Use of lipid-lowering medicinal herbs during pregnancy: A systematic review on safety and dosage.

作者信息

Rouhi-Boroujeni Hojjat, Heidarian Esfandiar, Rouhi-Boroujeni Hamid, Khoddami Minasadat, Gharipour Mojgan, Rafieian-Kopaei Mahmoud

机构信息

PhD Candidate, Student Research Committee AND Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Professor, Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

出版信息

ARYA Atheroscler. 2017 May;13(3):135-155.

PMID:29147122

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5677329/

Abstract

BACKGROUND

Hyperlipidemia is one of the important diseases in pregnancy that causes fetal abnormalities during pregnancy and after the birth. Unfortunately, the usual anti-fat drugs are associated with high morbidity in fetus and due to people's inclination towards taking herbs, it is required to identify side effects of medicinal herbs in pregnancy. The aim of this study was to present hypolipidemic herbs that would not any complications for mother and fetus.

METHODS

In this review article, the major electronic databases such as EBSCO, Central Register of Controlled Trials (CENTRAL), China Network Knowledge Infrastructure (CNKI), Cochrane, Google scholar, MEDLINE, SciVerse, Scopus, and Web of Science were searched using the key words "herbal" and "hyperlipidemia", "herbal" and "pregnancy" matched by MeSH from their respective inceptions till September, 2016. Total of 1723 publications (145 review articles, 855 original research articles, and 723 abstracts) about the effect of herbals on hyperlipidemia and 682 publications (200 abstracts, 423 original research articles, and 59 review articles) about the effect of herbals in pregnancy were retrieved. At the end, a list of medicinal plants effective on hyperlipidemia alongside their effects on pregnancy was developed. Finally, the plants effective on hyperlipidemia and safe during pregnancy were determined and their dosage, complications, mechanism of action, and side effects were reported.

RESULTS

A total of 110 effective herbs on hyperlipidemia were identified and complications of 95 plants in pregnancy were studied. At last, among the 55 selected plants effective on hyperlipidemia and examined for pregnancy, we reported 12 herbs with their dosage and special considerations that can be used to treat hyperlipidemia during pregnancy.

CONCLUSION

Some medicinal plants can be used to treat hyperlipidemia during pregnancy without any significant side effects both on mother or fetus.

摘要

背景

高脂血症是妊娠期重要疾病之一，可导致孕期及产后胎儿异常。遗憾的是，常用的抗脂药物与胎儿高发病率相关，且由于人们倾向于服用草药，因此需要确定孕期草药的副作用。本研究的目的是介绍对母亲和胎儿均无任何并发症的降血脂草药。

方法

在这篇综述文章中，使用关键词“草药”和“高脂血症”、“草药”和“妊娠”，通过医学主题词（MeSH）从其各自创建至2016年9月，检索了主要电子数据库，如EBSCO、对照试验中央注册库（CENTRAL）、中国知网（CNKI）、考科蓝图书馆、谷歌学术、医学文献数据库（MEDLINE）、SciVerse、Scopus和科学引文索引（Web of Science）。共检索到1723篇关于草药对高脂血症影响的出版物（145篇综述文章、855篇原创研究文章和723篇摘要）以及682篇关于草药对妊娠影响的出版物（200篇摘要、423篇原创研究文章和59篇综述文章）。最后，列出了对高脂血症有效的药用植物及其对妊娠的影响。最终，确定了对高脂血症有效且孕期安全的植物，并报告了它们的剂量、并发症、作用机制和副作用。