在成年个体中诱导经典移植耐受。
Induction of classical transplantation tolerance in the adult.
作者信息
Qin S X, Cobbold S, Benjamin R, Waldmann H
机构信息
Department of Pathology, University of Cambridge, United Kingdom.
出版信息
J Exp Med. 1989 Mar 1;169(3):779-94. doi: 10.1084/jem.169.3.779.
Abstract
Transplantation tolerance across histoincompatibilities in multiple non-H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A into CBA/Ca) antigens has been achieved successfully by combined adult bone marrow transplantation and treatment with CD4 and CD8 mAbs. The tolerant state was confirmed by permanent acceptance of donor strain skin grafts, and in vitro unresponsiveness to donor cells. Tolerance was associated with partial donor chimerism to various degrees. Tolerance to minor transplantation antigens induced in this manner was restricted to recipient-type MHC. The possibility was raised that tolerance resulted, at least in part, from clonal anergy rather than deletion.
摘要
通过成年骨髓移植联合CD4和CD8单克隆抗体治疗，已成功实现了在多个非H-2次要抗原（将B10.BR小鼠的骨髓移植到CBA/Ca小鼠）以及“次要”抗原加H-2D抗原（将B10.A小鼠的骨髓移植到CBA/Ca小鼠）不相容情况下的移植耐受。通过永久接受供体品系皮肤移植以及体外对供体细胞无反应性，证实了耐受状态。耐受与不同程度的部分供体嵌合体有关。以这种方式诱导的对次要移植抗原的耐受仅限于受体型MHC。这就提出了一种可能性，即耐受至少部分是由克隆无能而非克隆缺失导致的。
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本文引用的文献
1
Actively acquired tolerance of foreign cells.对外源细胞的主动获得性耐受。
Nature. 1953 Oct 3;172(4379):603-6. doi: 10.1038/172603a0.
2
Monoclonal antibodies against rat immunoglobulin kappa chains.抗大鼠免疫球蛋白κ链单克隆抗体。
Hybridoma. 1982;1(2):125-31. doi: 10.1089/hyb.1.1982.1.125.
3
Self tolerance is H-2-restricted.自身耐受性受H-2限制。
Nature. 1984;308(5961):738-41. doi: 10.1038/308738a0.
4
Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigens.H-2复合体在诱导T细胞对自身次要组织相容性抗原产生耐受性中的作用。
J Exp Med. 1983 Nov 1;158(5):1483-97. doi: 10.1084/jem.158.5.1483.
5
6
Immunohistological screening in the selection of monoclonal antibodies: the use of isotype-specific antiglobulins.单克隆抗体选择中的免疫组织学筛选：同种型特异性抗球蛋白的应用。
J Immunol Methods. 1984 Apr 27;69(2):207-14. doi: 10.1016/0022-1759(84)90319-3.
7
Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts.用同基因加异基因或异种骨髓进行重建可导致对同种异体移植物或异种移植物的特异性接受。
Nature. 1984;307(5947):168-70. doi: 10.1038/307168a0.
8
Proteolysis of rat IgG subclasses by Staphylococcus aureus V8 proteinase.金黄色葡萄球菌V8蛋白酶对大鼠IgG亚类的蛋白水解作用。
Biochim Biophys Acta. 1983 Oct 28;748(2):205-12. doi: 10.1016/0167-4838(83)90296-0.
9
Renal allograft tolerance induced with ATG and donor bone marrow in outbred rhesus monkeys.在远交恒河猴中用抗胸腺细胞球蛋白和供体骨髓诱导肾移植耐受。
Transplantation. 1983 Jul;36(1):104-6.
10
Evidence from in vitro studies that tolerance to self antigens is MHC-restricted.来自体外研究的证据表明，对自身抗原的耐受性是受主要组织相容性复合体（MHC）限制的。
Nature. 1984;308(5961):741-4. doi: 10.1038/308741a0.
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