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牙周病用漱口剂和牙膏中的活性成分的最新进展。

Recent Development of Active Ingredients in Mouthwashes and Toothpastes for Periodontal Diseases.

机构信息

The Center for Wound Healing and Tissue Regeneration, Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA.

Colgate-Palmolive Company, Piscataway, NJ 08854, USA.

出版信息

Molecules. 2021 Apr 1;26(7):2001. doi: 10.3390/molecules26072001.

DOI:10.3390/molecules26072001
PMID:33916013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8037529/
Abstract

Periodontal diseases like gingivitis and periodontitis are primarily caused by dental plaque. Several antiplaque and anti-microbial agents have been successfully incorporated into toothpastes and mouthwashes to control plaque biofilms and to prevent and treat gingivitis and periodontitis. The aim of this article was to review recent developments in the antiplaque, anti-gingivitis, and anti-periodontitis properties of some common compounds in toothpastes and mouthwashes by evaluating basic and clinical studies, especially the ones published in the past five years. The common active ingredients in toothpastes and mouthwashes included in this review are chlorhexidine, cetylpyridinium chloride, sodium fluoride, stannous fluoride, stannous chloride, zinc oxide, zinc chloride, and two herbs-licorice and curcumin. We believe this comprehensive review will provide useful up-to-date information for dental care professionals and the general public regarding the major oral care products on the market that are in daily use.

摘要

牙周病,如牙龈炎和牙周炎,主要由牙菌斑引起。许多抗菌斑和抗菌剂已成功地被添加到牙膏和漱口水中,以控制菌斑生物膜,并预防和治疗牙龈炎和牙周炎。本文旨在通过评估基础和临床研究,特别是过去五年发表的研究,综述牙膏和漱口水中一些常见化合物在抗菌斑、抗牙龈炎和抗牙周炎特性方面的最新进展。本综述中包含的牙膏和漱口水中的常见活性成分有洗必泰、十六烷基吡啶氯、氟化钠、氟化亚锡、氯化亚锡、氧化锌、氯化锌,以及两种草药-甘草和姜黄。我们相信,这篇全面的综述将为牙科保健专业人员和公众提供有关市场上日常使用的主要口腔护理产品的有用的最新信息。

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Antiviral Res. 2020 Jul;179:104818. doi: 10.1016/j.antiviral.2020.104818. Epub 2020 May 11.
2
Gingivitis efficacy of a 0.454% w/w stannous fluoride dentifrice: a 24-week randomized controlled trial.一种 0.454% w/w 氟化亚锡牙膏对牙龈炎的疗效:一项 24 周的随机对照试验。
BMC Oral Health. 2020 Mar 26;20(1):89. doi: 10.1186/s12903-020-01079-6.
3
Effects of Chlorhexidine mouthwash on the oral microbiome.洗必泰含漱液对口腔微生物组的影响。
Sci Rep. 2020 Mar 24;10(1):5254. doi: 10.1038/s41598-020-61912-4.
4
Oral biofilms exposure to chlorhexidine results in altered microbial composition and metabolic profile.口腔生物膜暴露于洗必泰后,微生物组成和代谢谱发生改变。
NPJ Biofilms Microbiomes. 2020 Mar 20;6(1):13. doi: 10.1038/s41522-020-0124-3.
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Comparative Fluoride Release and Antimicrobial Analysis of Commercial and Experimental Bioactive Glass/Nano-Oxide-Based Dentifrices.商业和实验性生物活性玻璃/纳米氧化物基牙膏的氟释放及抗菌性能比较分析
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