Hirata Hiroaki, Sokabe Masahiro
Mechanobiology Institute; National University of Singapore ; Singapore.
Mechanobiology Institute; National University of Singapore ; Singapore ; Mechanobiology Laboratory; Nagoya University Graduate School of Medicine ; Nagoya, Japan.
Commun Integr Biol. 2015 Apr 29;8(2):e1017176. doi: 10.1080/19420889.2015.1017176. eCollection 2015 Mar-Apr.
Intracellular and extracellular mechanical environments have a significant impact on survival and proliferation of cells. While the extracellular signal-regulated kinase (ERK) subfamily of MAP kinases plays critical roles in regulations of these cellular behaviors, activation of ERK is affected by mechanical conditions of cells. We have recently found that ERK is activated on contractile actomyosin bundles. ERK activation on actomyosin bundles depends on tension in the bundles, which is generated by either myosin II activity of external forces. In this Addendum, we discuss a novel, potential role of actomyosin bundles in ERK signaling and mechanical regulation of cell survival and proliferation.
细胞内和细胞外的力学环境对细胞的存活和增殖有重大影响。虽然丝裂原活化蛋白激酶（MAP激酶）的细胞外信号调节激酶（ERK）亚家族在这些细胞行为的调节中起关键作用，但ERK的激活受细胞力学条件的影响。我们最近发现，ERK在收缩性肌动球蛋白束上被激活。肌动球蛋白束上的ERK激活取决于束中的张力，这种张力是由肌球蛋白II活性或外力产生的。在本附录中，我们讨论了肌动球蛋白束在ERK信号传导以及细胞存活和增殖的力学调节中的一种新的潜在作用。
