Song Fuhai, Qian Ying, Peng Xing, Han Guangchun, Wang Jiajia, Bai Zhouxian, Crack Peter J, Lei Hongxing
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Curr Opin Pharmacol. 2016 Feb;26:47-53. doi: 10.1016/j.coph.2015.09.015. Epub 2015 Oct 19.
Alzheimer's disease (AD) is a neurodegenerative disease with broad impact. Although Aβ and tau have been proposed as the key molecules in the disease mechanism, comprehensive understanding of AD pathogenesis requires a systemic view at the genomic level. From studies on the brain transcriptome of AD, we have gradually realized the contribution of the immune system to AD development. Recent explorations on the blood transcriptome of AD patients have revealed robust immune activation in the peripheral blood. The combination of transcriptome studies and other types of studies has further elucidated the roles of specific immune pathways in distinct cell types during AD development and highlighted the critical contributions from immune genes such as TREM2.
阿尔茨海默病（AD）是一种具有广泛影响的神经退行性疾病。尽管β淀粉样蛋白（Aβ）和tau蛋白被认为是该疾病机制中的关键分子，但要全面了解AD的发病机制，需要在基因组水平上进行系统的研究。通过对AD患者大脑转录组的研究，我们逐渐认识到免疫系统对AD发展的作用。最近对AD患者血液转录组的探索揭示了外周血中强烈的免疫激活。转录组研究与其他类型研究的结合，进一步阐明了特定免疫途径在AD发展过程中在不同细胞类型中的作用，并突出了如触发受体表达于髓样细胞2（TREM2）等免疫基因的关键作用。
