Hartung Tim J, Mehnert Anja, Friedrich Michael, Hartmann Michael, Vehling Sigrun, Bokemeyer Carsten, Oechsle Karin
Department of Medical Psychology and Medical Sociology, University Medical Center Leipzig, Leipzig, Germany.
Department of Medical Psychology and Medical Sociology, University Medical Center Leipzig, Leipzig, Germany; Department and Outpatient Clinic of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Urol Oncol. 2016 Feb;34(2):60.e1-6. doi: 10.1016/j.urolonc.2015.09.005. Epub 2015 Oct 21.
To compare long-term health-related quality of life (QoL) in germ cell tumor survivors (GCTS) and age-adjusted men and to identify predictors of variation in long-term QoL in GCTS.
We used the Short-Form Health Survey to measure QoL in a cross-sectional sample of 164 survivors of germ cell tumors from Hamburg, Germany. QoL was compared with age-adjusted German norm data. Sociodemographic and medical data from questionnaires and medical records were used to find predictors of QoL.
On average, patients were 44.4 years old (standard deviation = 9.6 y) and average time since first germ cell tumor diagnosis was 11.6 years (standard deviation = 7.3 y). We found significantly lower mental component scores in GCTS when compared with norm data (Hedges g =-0.44, P<0.001). An exploratory analysis by age group showed the largest difference in mental QoL in survivors aged 31 to 40 years (Hedges g =-0.67). Linear regression analysis revealed age (β =-0.46, P<0.001), marital status (β = 0.20, P = 0.024), advanced secondary qualifications (β =-0.25, P = 0.001), time since diagnosis (β = 0.17, P = 0.031), and tumor stage (β = 0.17, P = 0.024) as statistically significant predictors of the physical component score, accounting for 22% of the variance. Statistically significant predictors of the mental component score were higher secondary qualifications (β = 0.17, P = 0.033) and unemployment (β =-0.21, P = 0.009), accounting for 6% of the variance.
Survivors of germ cell tumors can expect an overall long-term QoL similar to that of other men of their age.
比较生殖细胞肿瘤幸存者（GCTS）与年龄匹配男性的长期健康相关生活质量（QoL），并确定GCTS长期QoL变化的预测因素。
我们使用简短健康调查问卷对来自德国汉堡的164名生殖细胞肿瘤幸存者的横断面样本进行QoL测量。将QoL与年龄匹配的德国标准数据进行比较。通过问卷和病历收集的社会人口学和医学数据用于寻找QoL的预测因素。
患者平均年龄为44.4岁（标准差=9.6岁），自首次诊断生殖细胞肿瘤以来的平均时间为11.6年（标准差=7.3年）。与标准数据相比，我们发现GCTS的心理成分得分显著更低（Hedges g=-0.44，P<0.001）。按年龄组进行的探索性分析显示，31至40岁幸存者的心理QoL差异最大（Hedges g=-0.67）。线性回归分析显示，年龄（β=-0.46，P<0.001）、婚姻状况（β=0.20，P=0.024）、高等中学学历（β=-0.25，P=0.001）、诊断后的时间（β=0.17，P=0.031）和肿瘤分期（β=0.17，P=0.024）是身体成分得分的统计学显著预测因素，解释了22%的方差。心理成分得分的统计学显著预测因素是高等中学学历（β=0.17，P=0.033）和失业（β=-0.21，P=0.009），解释了6%的方差。
生殖细胞肿瘤幸存者的总体长期QoL有望与同龄其他男性相似。
