白塞病中的脊髓受累
Spinal cord involvement in Behçet's disease.
作者信息
Lee Hyung Seok, Kim Do Young, Shin Ha Young, Choi Young-Chul, Kim Seung Min
机构信息
Department of Neurology, Yonsei University College of Medicine, Republic of Korea.
Department of Dermatology, Yonsei University College of Medicine, Republic of Korea.
出版信息
Mult Scler. 2016 Jun;22(7):960-3. doi: 10.1177/1352458515613642. Epub 2015 Oct 19.
BACKGROUND
Spinal cord involvement in Behçet's disease is not well studied.
OBJECTIVE
To evaluate the clinical, laboratory and magnetic resonance imaging characteristics of spinal cord involvement in Behçet's disease.
METHODS
We retrospectively reviewed 10 spinal cord involvements in seven patients with Behçet's disease.
RESULTS
The median age of onset for spinal cord involvement was 32 (23-45 years). Two patients showed a secondary progressive course. Cerebrospinal fluid findings revealed mild to moderate pleocytosis and/or elevated protein levels. In eight spinal cord involvements, the lesion was longer than three vertebrae. Serum anti-aquaporin-4 antibody was negative in all four patients tested.
CONCLUSIONS
Longitudinally extensive transverse myelitis is a characteristic manifestation of spinal cord involvement in Behçet's disease.
背景
白塞病脊髓受累情况尚未得到充分研究。
目的
评估白塞病脊髓受累的临床、实验室及磁共振成像特征。
方法
我们回顾性分析了7例白塞病患者的10次脊髓受累情况。
结果
脊髓受累的中位发病年龄为32岁（23 - 45岁）。2例患者呈继发进展型病程。脑脊液检查结果显示轻度至中度细胞增多和/或蛋白水平升高。在8次脊髓受累中，病变长度超过三个椎体。所有4例接受检测的患者血清抗水通道蛋白4抗体均为阴性。
结论
纵向广泛横贯性脊髓炎是白塞病脊髓受累的特征性表现。
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