Bootsman Florian, Brouwer Rachel M, Kemner Sanne M, Schnack Hugo G, van der Schot Astrid C, Vonk Ronald, Hillegers Manon H J, Boomsma Dorret I, Hulshoff Pol Hilleke E, Nolen Willem A, Kahn René S, van Haren Neeltje E M
University Medical Center Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.
University Medical Center Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.
Eur Neuropsychopharmacol. 2015 Dec;25(12):2197-209. doi: 10.1016/j.euroneuro.2015.09.023. Epub 2015 Oct 8.
The influence of genes and environment on the association between bipolar disorder (BD) and volumes of subcortical brain regions involved in emotion processing has rarely been studied. Furthermore, as far as we know, longitudinal twin studies of subcortical brain volume change in BD have not been carried out at all. In this study, we focused on the genetic and environmental contributions to cross-sectional and longitudinal measures of subcortical brain volumes in BD. A total of 99 twins from monozygotic and dizygotic pairs concordant or discordant for BD and 129 twins from monozygotic and dizygotic healthy control pairs underwent magnetic resonance imaging at baseline. Longitudinal assessment was carried out in 48 twins from monozygotic and dizygotic patient pairs and 52 twins from monozygotic and dizygotic control pairs. Subcortical volume measures were obtained with Freesurfer software and analyzed with structural equation modeling software OpenMx. At baseline, BD was phenotypically and genetically associated with smaller volumes of the thalamus, putamen and nucleus accumbens. BD was not associated with subcortical brain volume change over time in any of the examined regions. Heritability of subcortical volumes at baseline was high, whereas subcortical volume change had low heritability. Genes contributing to BD showed overlap with those associated with smaller volumes of the thalamus, putamen and nucleus accumbens at baseline. Further evaluation of genetic contributions to abnormalities in subcortical brain regions assumed to be involved in emotion processing is recommended.
基因和环境对双相情感障碍（BD）与参与情绪处理的大脑皮质下区域体积之间关联的影响鲜有研究。此外，据我们所知，尚未开展关于BD患者大脑皮质下体积变化的纵向双胞胎研究。在本研究中，我们聚焦于基因和环境对BD患者大脑皮质下体积的横断面和纵向测量的影响。共有99对同卵和异卵双胞胎，其中一些双胞胎患有BD，另一些未患病，以及129对同卵和异卵健康对照双胞胎在基线时接受了磁共振成像检查。对48对同卵和异卵患病双胞胎以及52对同卵和异卵对照双胞胎进行了纵向评估。使用Freesurfer软件获取大脑皮质下体积测量值，并使用结构方程建模软件OpenMx进行分析。在基线时，BD在表型和基因上与丘脑、壳核和伏隔核体积较小有关。在任何检查区域，BD与大脑皮质下体积随时间的变化均无关联。基线时大脑皮质下体积的遗传度较高，而大脑皮质下体积变化的遗传度较低。导致BD的基因与基线时与丘脑、壳核和伏隔核体积较小相关的基因存在重叠。建议进一步评估基因对假定参与情绪处理的大脑皮质下区域异常的影响。
