Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
Curr Top Behav Neurosci. 2021;48:173-196. doi: 10.1007/7854_2020_174.
The search for brain morphology findings that could explain behavioral disorders has gone through a long path in the history of psychiatry. With the advance of brain imaging technology, studies have been able to identify brain morphology and neural circuits associated with the pathophysiology of mental illnesses, such as bipolar disorders (BD). Promising results have also shown the potential of neuroimaging findings in the identification of outcome predictors and response to treatment among patients with BD. In this chapter, we present brain imaging structural and functional findings associated with BD, as well as their hypothesized relationship with the pathophysiological aspects of that condition and their potential clinical applications.
寻找能够解释行为障碍的大脑形态学发现,这在精神病学的历史上经历了漫长的道路。随着脑成像技术的进步,研究已经能够识别与精神疾病(如双相情感障碍)的病理生理学相关的大脑形态和神经回路。有希望的结果还表明,神经影像学发现有可能确定双相情感障碍患者的预后预测因子和治疗反应。在本章中,我们介绍了与双相情感障碍相关的脑影像学结构和功能发现,以及它们与该疾病病理生理学方面的假设关系及其潜在的临床应用。