Serdar Açıkgöz Abdullah, Tüten Abdullah, Öncül Mahmut, Eskalen Şerife, Çakmak Dinçgez Burcu, Şimşek Arife, Aytaç Yüksel Mehmet, Guralp Onur
a Department of Gynecology and Obstetrics , Cerrahpasa Faculty of Medicine, Istanbul University , Istanbul , Turkey .
b Department of General Surgery , Cerrahpasa Faculty of Medicine, Istanbul University , Istanbul , Turkey .
J Matern Fetal Neonatal Med. 2016;29(16):2658-64. doi: 10.3109/14767058.2015.1096338. Epub 2015 Oct 20.
To investigate the possible pathophysiological associations between progranulin (PGRN) and preeclampsia (PE), early-onset PE (EOPE) and late-onset PE (LOPE).
A cross-sectional study was designed to include consecutive patients with uncomplicated pregnancy (n = 28), EOPE (n = 30) and LOPE (n = 22). Maternal levels of serum PGRN were measured with the use of an enzyme-linked immunosorbent assay kit.
The mean serum PGRN level was significantly higher in women with PE compared to the control group (54.17 ± 4.20 pg/ml versus 42.37 ± 5.64 pg/ml, p < 0.001), in the LOPE group compared to the control group (51.63 ± 4.61 pg/ml versus 42.37 ± 5.64 pg/ml, p < 0.001) and also in women with EOPE compared to women with LOPE (56.03 ± 2.68 pg/ml versus 51.63 ± 4.61 pg/ml, p < 0.001). Serum PGRN was negatively correlated with gestational age at birth (r = -0.669, p = 0.001) and birth weight (r = -0.653, p = 0.001); and positively correlated with systolic (r = 0.653, p = 0.001) and diastolic blood pressure (r = 0.601, p = 0.001), C-reactive protein (r = 0.519, p = 0.001), uterine artery pulsatility (r = 0.441, p = 0.001) and resistance indices (r = 0.441, p = 0.001).
Serum PGRN levels increase significantly in women with PE as an indirect sign of placental dysfunction. This increase is even more prominent in women with EOPE. The serum PGRN in the third trimester is positively correlated with gestational age at birth and birth weight.
探讨颗粒前体蛋白（PGRN）与子痫前期（PE）、早发型子痫前期（EOPE）和晚发型子痫前期（LOPE）之间可能的病理生理联系。
一项横断面研究纳入了连续的无并发症妊娠患者（n = 28）、早发型子痫前期患者（n = 30）和晚发型子痫前期患者（n = 22）。使用酶联免疫吸附测定试剂盒测量母体血清PGRN水平。
与对照组相比，子痫前期患者的平均血清PGRN水平显著更高（54.17±4.20 pg/ml对42.37±5.64 pg/ml，p<0.001）；与对照组相比，晚发型子痫前期组的平均血清PGRN水平也显著更高（51.63±4.61 pg/ml对42.37±5.64 pg/ml，p<0.001）；早发型子痫前期患者的平均血清PGRN水平高于晚发型子痫前期患者（56.03±2.68 pg/ml对51.63±4.61 pg/ml，p<0.001）。血清PGRN与出生时的孕周（r = -0.669，p = 0.001）和出生体重（r = -0.653，p = 0.001）呈负相关；与收缩压（r = 0.653，p = 0.001）、舒张压（r = 0.601，p = 0.001）、C反应蛋白（r = 0.519，p = 0.001）、子宫动脉搏动指数（r = 0.441，p = 0.001）和阻力指数（r = 0.441，p = 0.001）呈正相关。
子痫前期患者血清PGRN水平显著升高，这是胎盘功能障碍的间接征象。这种升高在早发型子痫前期患者中更为明显。孕晚期血清PGRN与出生时的孕周和出生体重呈正相关。
