早发型和晚发型子痫前期患者的血清collectrin水平。

Serum collectrin levels in patients with early- and late-onset preeclampsia.

作者信息

Aslan Cetin Berna, Aydogan Mathyk Begum, Cift Tayfur, Tuten Abdullah, Bulut Berk, Yilmaz Nevin, Erenel Hakan, Ekmekci Hakan, Gezer Altay

机构信息

a Department of Obstetrics and Gynecology , Kanuni Sultan Suleyman Research and Training Hospital , Istanbul , Turkey.

b Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility , University of North Carolina , Chapel Hill , NC , USA.

出版信息

J Matern Fetal Neonatal Med. 2018 Nov;31(21):2827-2831. doi: 10.1080/14767058.2017.1357692. Epub 2017 Aug 2.

DOI:10.1080/14767058.2017.1357692

PMID:28764560

Abstract

AIM

The aim of this study is to investigate the maternal levels of collectrin in early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). To assess the correlation between serum collectrin levels and blood pressure in humans.

MATERIAL AND METHODS

This cross-sectional study was conducted including 79 pregnant women, 27 with normal pregnancy, 30 with EOPE and 22 with LOPE. Maternal serum levels of collectrin were measured by using enzyme-linked immunosorbent assay kits.

RESULTS

The mean serum collectrin level was significantly lower in women with PE compared with the control group (8.49 ± 3.12 ng/ml (EOPE), 9.69 ± 3.01 ng/ml (LOPE) versus 11.51 ± 4.33 ng/ml) and was found to be the lowest in the EOPE group (8.49 ± 3.12 ng/ml). The mean serum urea and uric acid levels were significantly higher in the PE group than the control group. Serum collectrin concentrations did not correlate with maternal age, BMI and serum creatinine levels. However, collectrin concentrations were negatively correlated with systolic blood pressure (r = -0.284, p = .011) and diastolic blood pressure (r = -0.275, p = .014) as well as with maternal serum urea (r = -0.269, p = .017) and uric acid (r = -0.219, p = .049) concentrations.

CONCLUSION

Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure.

摘要

目的

本研究旨在调查早发型子痫前期（EOPE）和晚发型子痫前期（LOPE）患者母体中collectrin的水平。评估人体血清collectrin水平与血压之间的相关性。

材料与方法

本横断面研究纳入了79名孕妇，其中27名正常妊娠，30名早发型子痫前期患者，22名晚发型子痫前期患者。使用酶联免疫吸附测定试剂盒测量母体血清中collectrin的水平。

结果

与对照组相比，子痫前期患者的血清collectrin平均水平显著降低（早发型子痫前期组为8.49±3.12 ng/ml，晚发型子痫前期组为9.69±3.01 ng/ml，对照组为11.51±4.33 ng/ml），且早发型子痫前期组最低（8.49±3.12 ng/ml）。子痫前期组的血清尿素和尿酸平均水平显著高于对照组。血清collectrin浓度与产妇年龄、体重指数和血清肌酐水平无关。然而，collectrin浓度与收缩压（r = -0.284，p = 0.011）、舒张压（r = -0.275，p = 0.014）以及母体血清尿素（r = -0.269，p = 0.017）和尿酸（r = -0.219，p = 0.049）浓度呈负相关。