Fragu P
Laboratoire de Physiopathologie Thyroïdienne, INSERM U 66, Unité de Médecine Nucléaire, Villejuif, France.
Pathol Biol (Paris). 1989 Jan;37(1):59-66.
Optimization of the utilization of a new radioimmunoassay (RIA) requires the identification of explicit criteria regarding when this new RIA should be used. The first step consists in the definition of the normal range on a well defined learning sample of patients. The authors describe the methods which can be used; mean and standard deviation, ROC analysis, Bayes theorem. These limits must be therefore validated on a control sample. The second step of this diagnostic evaluation must estimate the impact of the new RIA on the medical decision procedure. The historical account of thyroid function testing illustrates these different points.
优化一种新的放射免疫分析（RIA）的应用需要确定关于何时应使用这种新RIA的明确标准。第一步是在定义明确的患者学习样本上确定正常范围。作者描述了可以使用的方法；均值和标准差、ROC分析、贝叶斯定理。因此，这些界限必须在对照样本上进行验证。这种诊断评估的第二步必须估计新RIA对医疗决策程序的影响。甲状腺功能测试的历史记录说明了这些不同的要点。
