Dos Santos Mélanie, Bouhier Karine, Dao Manh-Thong
Mélanie Dos Santos, Karine Bouhier, Manh-Thong Dao, Department of Gastroenterology, CHU de Caen, 14000 Caen, France.
World J Gastrointest Oncol. 2015 Oct 15;7(10):259-62. doi: 10.4251/wjgo.v7.i10.259.
Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter (G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid reaction with a white blood cell count of 63.87 G/L without identified infectious, iatrogenic or hematologic causes. His overall condition quickly degraded and he died three weeks after the discovery of the leukemoid reaction. This is the first case in French literature of leukemoid reaction in a patient with pancreatic carcinoma with poor prognostic value.
副肿瘤性类白血病反应是一种罕见综合征,定义为白细胞计数超过50千兆/升(G/L),多见于进展期肺癌或肾癌。我们报告一例68岁男性复发性胰腺癌患者,出现类白血病反应,白细胞计数为63.87 G/L,未发现感染、医源性或血液学病因。其整体状况迅速恶化,在发现类白血病反应三周后死亡。这是法国文献中首例胰腺癌患者出现类白血病反应且预后不良的病例。