Hocking W, Goodman J, Golde D
Blood. 1983 Mar;61(3):600-3.
A patient with metastatic soft tissue sarcoma presented with a leukemoid reaction. The elevated white blood cell count was due to an increase in bands and mature segmented neutrophils. The degree of granulocytosis correlated with the tumor burden. There was no evidence of superimposed infection and the degree of bone marrow involvement by metastatic tumor was minimal. A cell line derived from the sarcoma produces granulocyte-macrophage colony-stimulating activity (CSA) in vitro. Although CSA could not be detected in serum, the findings in this patient suggest that the leukemoid reaction was due to tumor production of CSA.
一名转移性软组织肉瘤患者出现类白血病反应。白细胞计数升高是由于杆状核和成熟分叶核中性粒细胞增多所致。粒细胞增多的程度与肿瘤负荷相关。没有叠加感染的证据，转移性肿瘤对骨髓的累及程度最小。从肉瘤中提取的细胞系在体外可产生粒细胞-巨噬细胞集落刺激活性（CSA）。虽然血清中未检测到CSA，但该患者的发现提示类白血病反应是由肿瘤产生CSA所致。
