Cheon Mi Kyung, Na Hyunju, Han Seung Beom, Kwon Hyo Jin, Chun Yoon Hong, Kang Jin Han
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. ; Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Infect Chemother. 2015 Sep;47(3):197-201. doi: 10.3947/ic.2015.47.3.197. Epub 2015 Sep 30.
Recently, the incidence of pertussis has been increasing; however, reports on mixed infection of pertussis with other respiratory pathogens are rare in highly immunized populations. We report the case of a 10-year-old girl who presented with cough, post-tussive emesis, and fever. She was subsequently diagnosed with bronchopneumonia. Although she had received five doses of diphtheria-tetanus-acellular pertussis vaccine, polymerase chain reaction of her nasopharyngeal aspirate confirmed Bordetella pertussis infection. In addition, serologic testing for Mycoplasma pneumoniae was also positive. The patient was treated with roxithromycin without any complications. This is the first report of mixed B. pertussis and M. pneumoniae infection in Korea. To avoid under-diagnosis, pertussis should be considered in patients with chronic cough even when other respiratory pathogens have been documented.
最近,百日咳的发病率一直在上升;然而,在高免疫人群中,关于百日咳与其他呼吸道病原体混合感染的报道很少。我们报告了一名10岁女孩的病例,她出现咳嗽、咳嗽后呕吐和发热症状。随后她被诊断为支气管肺炎。尽管她已接种五剂白喉-破伤风-无细胞百日咳疫苗,但她的鼻咽抽吸物聚合酶链反应证实感染了百日咳博德特氏菌。此外,肺炎支原体的血清学检测也呈阳性。患者接受罗红霉素治疗,未出现任何并发症。这是韩国首例百日咳博德特氏菌和肺炎支原体混合感染的报告。为避免漏诊,即使已记录有其他呼吸道病原体,对于慢性咳嗽患者也应考虑百日咳。