Khatri Indu, Subramanian Srikrishna, Mayilraj Shanmugam
Protein Science and Engineering, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.
Microbial Type Culture Collection and Gene Bank (MTCC), CSIR-Institute of Microbial Technology, Chandigarh 160036, India.
Genom Data. 2014 Mar 12;2:44-5. doi: 10.1016/j.gdata.2013.12.003. eCollection 2014 Dec.
We report the 9.2 Mb genome of the azureomycin A and B antibiotic producing strain Amycolatopsis azurea isolated from a Japanese soil sample. The draft genome of strain DSM 43854(T) consists of 9,223,451 bp with a G + C content of 69.0% and the genome contains 3 rRNA genes (5S-23S-16S) and 58 aminoacyl-tRNA synthetase genes. The homology searches revealed that the PKS gene clusters are supposed to be responsible for the biosynthesis of naptomycin, macbecin, rifamycin, mitomycin, maduropeptin enediyne, neocarzinostatin enediyne, C-1027 enediyne, calicheamicin enediyne, landomycin, simocyclinone, medermycin, granaticin, polyketomycin, teicoplanin, balhimycin, vancomycin, staurosporine, rubradirin and complestatin.
我们报道了从一份日本土壤样本中分离出的产天青菌素A和B抗生素的菌株蔚蓝拟无枝酸菌的9.2 Mb基因组。菌株DSM 43854(T)的基因组草图由9,223,451 bp组成，G + C含量为69.0%，该基因组包含3个rRNA基因（5S - 23S - 16S）和58个氨酰 - tRNA合成酶基因。同源性搜索显示，聚酮合酶（PKS）基因簇可能负责那他霉素、马贝菌素、利福霉素、丝裂霉素、马杜拉霉素烯二炔、新制癌菌素烯二炔、C - 1027烯二炔、加利车霉素烯二炔、兰卡霉素、西罗莫司菌素、美登霉素、石榴菌素、聚酮霉素、替考拉宁、巴利昔霉素、万古霉素、星形孢菌素、鲁布拉迪菌素和复合他汀的生物合成。
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