细菌细胞壁抑制剂的研究。VII. 天蓝霉素A和B，新的抗生素，由天蓝假诺卡氏菌新种产生。产生菌的分类学、分离、特性及生物学特性 。
Studies on bacterial cell wall inhibitors. VII. Azureomycins A and B, new antibiotics produced by Pseudonocardia azurea nov. sp. Taxonomy of the producing organism, isolation, characterization and biological properties.
作者信息
Omura S, Tanaka H, Tanaka Y, Spiri-Nakagawa P, Oiwa R, Takahashi Y, Matsuyama K, Iwai Y
出版信息
J Antibiot (Tokyo). 1979 Oct;32(10):985-94. doi: 10.7164/antibiotics.32.985.
PMID:528377
Abstract
Two new basic water-soluble antibiotics, azureomycins A and B, were isolated from the culture broth of an actinomycete, strain AM-3696, designated as Pseudonocardia azurea nov. sp. The antibiotics exhibit moderate antimicrobial activities against Gram-positive bacteria including penicillin-resistant Staphylococcus, Mycobacterium and Clostridium. They inhibit the synthesis of bacterial cell wall peptidoglycan.
摘要
从一株放线菌AM-3696（命名为天蓝假诺卡氏菌新种Pseudonocardia azurea nov. sp.）的培养液中分离出两种新的碱性水溶性抗生素，天蓝霉素A和天蓝霉素B。这两种抗生素对包括耐青霉素葡萄球菌、分枝杆菌和梭菌在内的革兰氏阳性菌具有中等抗菌活性。它们抑制细菌细胞壁肽聚糖的合成。
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