Kisil Olga V, Efimenko Tatiana A, Efremenkova Olga V
Gause Institute of New Antibiotics, 119021 Moscow, Russia.
Antibiotics (Basel). 2021 Oct 15;10(10):1254. doi: 10.3390/antibiotics10101254.
The emergence of antibiotic-resistant pathogenic bacteria in recent decades leads us to an urgent need for the development of new antibacterial agents. The species of the genus are known as producers of secondary metabolites that are used in medicine and agriculture. The complete genome sequences of the demonstrate a wide variety of biosynthetic gene clusters, which highlights the potential ability of actinomycetes of this genus to produce new antibiotics. In this review, we summarize information about antibiotics produced by species. This knowledge demonstrates the prospects for further study of this genus as an enormous source of antibiotics.
近几十年来，抗生素耐药性病原菌的出现使我们迫切需要开发新的抗菌剂。该属的物种是用于医药和农业的次生代谢产物的生产者。该属的全基因组序列显示出各种各样的生物合成基因簇，这突出了该属放线菌产生新抗生素的潜在能力。在这篇综述中，我们总结了有关该属物种产生的抗生素的信息。这些知识表明了将该属作为巨大抗生素来源进行进一步研究的前景。
