Seibert J J, McCowan T C, Chadduck W M, Adametz J R, Glasier C M, Williamson S L, Taylor B J, Leithiser R E, McConnell J R, Stansell C A
Department of Radiology, University of Arkansas for Medical Sciences, Little Rock.
Radiology. 1989 Apr;171(1):155-9. doi: 10.1148/radiology.171.1.2648468.
This study was conducted to determine if the resistive index (RI) could be used for the examination and follow-up of neonates with increased intracranial pressure. First, in a laboratory model with four mongrel dogs, RI was found to correlate linearly with cerebral perfusion pressure. Second, RI was studied in 57 healthy neonates and 285 neonates with abnormal clinical or head ultrasound findings. Average RI for healthy newborns was 75 +/- 10 and was inversely related to gestational age. RI in newborns with abnormal findings was uniformly elevated, but these values varied considerably and were not statistically different from normal values. Third, the RI was found to decrease significantly after patent ductus arteriosus ligation, tapping of subdural effusions, ventricular tapping (later cerebrospinal fluid shunting led to a further drop in RI), and ventriculoperitoneal shunting. Elevated RI indicates possible intra- or extracranial abnormality affecting cerebral blood flow. Doppler RI is valuable in following up neonates with abnormal or unstable conditions and in assessing the effectiveness of therapies to improve cerebral perfusion.
本研究旨在确定阻力指数（RI）是否可用于颅内压升高新生儿的检查和随访。首先，在一个有4只杂种狗的实验室模型中，发现RI与脑灌注压呈线性相关。其次，对57例健康新生儿和285例有异常临床或头部超声检查结果的新生儿进行了RI研究。健康新生儿的平均RI为75±10，且与胎龄呈负相关。有异常检查结果的新生儿的RI均升高，但这些值差异很大，与正常值无统计学差异。第三，发现动脉导管未闭结扎、硬膜下积液穿刺、脑室穿刺（随后脑脊液分流导致RI进一步下降）和脑室腹腔分流后RI显著降低。RI升高表明可能存在影响脑血流的颅内或颅外异常。多普勒RI在随访异常或不稳定状况的新生儿以及评估改善脑灌注治疗的有效性方面具有重要价值。
