基于纳米级UiO-金属有机框架的发光传感器用于高选择性检测半胱氨酸和谷胱甘肽及其在生物成像中的应用。
Nanoscale UiO-MOF-based luminescent sensors for highly selective detection of cysteine and glutathione and their application in bioimaging.
作者信息
Li Yan-An, Zhao Chao-Wei, Zhu Neng-Xiu, Liu Qi-Kui, Chen Gong-Jun, Liu Jian-Biao, Zhao Xiao-Dong, Ma Jian-Ping, Zhang Shaojun, Dong Yu-Bin
机构信息
College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China.
出版信息
Chem Commun (Camb). 2015 Dec 28;51(100):17672-5. doi: 10.1039/c5cc07783d. Epub 2015 Oct 22.
We report a practical approach, the first of its kind, to construct nanoscale UiO-type metal-organic framework (Mi-UiO-66 and Mi-UiO-67) fluorescent probes for the detection of Cys and GSH. They showed high sensitivity (10(-11) M) and selectivity for Cys and GSH, and their fluorescence imaging of Cys and GSH in living cells was well demonstrated.
我们报道了一种实用方法，这是首次构建用于检测半胱氨酸（Cys）和谷胱甘肽（GSH）的纳米级UiO型金属有机框架（Mi-UiO-66和Mi-UiO-67）荧光探针。它们对半胱氨酸和谷胱甘肽显示出高灵敏度（10⁻¹¹ M）和选择性，并且很好地证明了它们在活细胞中对半胱氨酸和谷胱甘肽的荧光成像。
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