Babu Ramesh
Department of Pediatric Urology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai 600116, India.
J Pediatr Urol. 2016 Apr;12(2):103.e1-4. doi: 10.1016/j.jpurol.2015.08.017. Epub 2015 Oct 8.
The management of primary obstructed megaureter (POM) ranges from temporary double-J stenting to conventional ureteric reimplantation with tapering. Of late, several authors have favored refluxing reimplantation. In the present study the outcomes of 'mini reimplantation', where no tapering or advancement of the ureter was performed, have been analyzed.
Records of all children (n = 28) who underwent reimplantation for POM from 2004 to 2014 were retrospectively analyzed. During the initial 5 years, a Cohen's reimplantation with excisional tapering was performed (Group 1, n = 15). Due to complications, the technique was modified in the second 5 years (Group 2, n = 13). In this group, after opening the bladder, the distal narrow segment and grossly dilated POM (around 3-5 cm) were excised (Figure). After closing the detrusor behind the ureter, the ureter was reimplanted again at the original position without tapering or advancement. Bladder mucosa was closed cranial to the new ureteric orifice, providing a ureter:tunnel ratio of 1:2 (mini reimplantation). All patients underwent repeat ultrasonogram and MAG3 renogram, with indirect at 6 months and 1 year after stent removal to exclude obstruction/vesicoureteral reflux (VUR).
In Group 1, a significantly higher proportion (P = 0.04) of patients (5/15) had to undergo repeat procedures for complications, compared with none in Group 2. In Group 1, there were two redo reimplants for recurrent obstructions; two nephrectomies for non-functioning kidneys; and one ureterostomy for pyonephrosis. Postoperative Grade 2-3 VUR was encountered in 3/15 patients in Group 1, and 2/13 patients in Group 2. These patients could be managed with antibiotic prophylaxis and no intervention was required.
Conventional management of POM involved initial cutaneous ureterostomy, followed by reimplantation with tapering of the ureter. Megaureter reimplantation with and without tapering has been reported to have no significant difference in outcomes between them. To avoid a potentially difficult operation in a small infant bladder, a refluxing reimplantation has been proposed; however, there is a high re-operation rate following this technique. The author feels that the reported technique is superior to the refluxing reimplantation, as there is no need for re-operation. The limitations of this study were the small numbers and short follow-up. However, the proposed 'mini reimplantation' with no tapering or advancement had good success rates in this small series. Further larger studies are required to support or negate the usefulness of this technique.
原发性梗阻性巨输尿管(POM)的治疗方法多样,从临时置入双J管到传统的输尿管裁剪再植术。近来,一些作者倾向于抗反流再植术。在本研究中,我们分析了“微型再植术”的治疗效果,该术式未对输尿管进行裁剪或移位。
回顾性分析2004年至2014年间因POM接受再植术的所有儿童(n = 28)的记录。在最初的5年中,采用了带切除性裁剪的科恩再植术(第1组,n = 15)。由于出现并发症,在随后的5年中对技术进行了改良(第2组,n = 13)。在该组中,打开膀胱后,切除远端狭窄段和明显扩张的POM(约3 - 5 cm)(图)。在输尿管后方关闭逼尿肌后,将输尿管在原位置再次植入,不进行裁剪或移位。膀胱黏膜在新输尿管口上方关闭,使输尿管与隧道的比例为1:2(微型再植术)。所有患者均接受了重复超声检查和MAG3肾图检查,在拔除支架后6个月和1年进行间接检查以排除梗阻/膀胱输尿管反流(VUR)。
第1组中,有更高比例(P = 0.04)的患者(5/15)因并发症需要再次手术,而第2组中无此情况。在第1组中,有2例因复发性梗阻进行了再次再植术;2例因肾功能丧失进行了肾切除术;1例因肾盂积脓进行了输尿管造口术。第1组中有3/15的患者术后出现2 - 3级VUR,第2组中有2/13的患者出现该情况。这些患者可通过抗生素预防进行处理,无需干预。
POM的传统治疗方法包括初始的皮肤输尿管造口术,随后进行输尿管裁剪再植术。据报道,有裁剪和无裁剪的巨输尿管再植术在治疗效果上无显著差异。为避免在小婴儿膀胱中进行潜在困难的手术,有人提出抗反流再植术;然而,该技术的再次手术率较高。作者认为所报道的技术优于抗反流再植术,因为无需再次手术。本研究的局限性在于样本量小和随访时间短。然而,在这个小系列中,所提出的不进行裁剪或移位的“微型再植术”成功率良好。需要进一步的大型研究来支持或否定该技术的实用性。