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改良输尿管原位再植术治疗婴儿原发性梗阻性巨输尿管的初步研究

Modified ureteral orthotopic reimplantation method for managing infant primary obstructive megaureter: a preliminary study.

作者信息

Liu Wei, Du Guoqiang, Guo Feng, Ma Rui, Wu Rongde

机构信息

Department of Pediatric Surgery, Provincial Hospital Affiliated To Shandong University, Jinan, 250021, China.

Department of Pediatric Surgery, The People's Hospital of Linyi City, Linyi, 276003, China.

出版信息

Int Urol Nephrol. 2016 Dec;48(12):1937-1941. doi: 10.1007/s11255-016-1409-6. Epub 2016 Sep 2.

DOI:10.1007/s11255-016-1409-6
PMID:27590133
Abstract

PURPOSE

To describe a modified ureteral orthotopic reimplantation method in infant with primary obstructive megaureter (POM) and report our initial experience.

METHODS

Thirteen children with POM (range 1-7 months) underwent modified transvesical ureteral implantation surgery. Treatment consists of transecting the ureter proximal to the obstruction and performing orthotopic reimplantation in end freely fashion with distal ureter protruding into the bladder, providing dilated ureteral diameter: ureteral exposure length in bladder ratio of 1:1.5-2. All patients underwent repeat ultrasound, radionuclide imaging and voiding cystourethrography. Cystoscopy was conducted in patients at 6 months after surgery.

RESULTS

The mean operating time was 40 min. There were one redo this procedure for recurrent obstruction and one Cohen reimplantation for Grade 5 vesico-ureteral reflux in one bilateral POM. Hydroureteronephrosis improved in other 11 patients, and the ureter diameter was significantly reduced from preoperative measurements. At the time of cystoscopy, thick and large volcanic-shaped ureteral orifice was found and urine ejected intermittently.

CONCLUSIONS

The proposed 'modified ureteral orthotopic reimplantation' with no tapering or advancement for POM in infants is a simple, feasible and less invasive procedure that had good success rates in this small series. Further, larger studies are required to support or negate the usefulness of this technique.

摘要

目的

描述一种改良的原发性梗阻性巨输尿管(POM)婴儿输尿管原位再植方法,并报告我们的初步经验。

方法

13例POM患儿(年龄1 - 7个月)接受改良经膀胱输尿管植入手术。治疗方法包括在梗阻近端横断输尿管,并将输尿管远端以末端自由方式原位再植,使其突出于膀胱内,使输尿管直径与输尿管在膀胱内的暴露长度之比为1:1.5 - 2。所有患者均接受了重复超声、放射性核素显像和排尿性膀胱尿道造影检查。术后6个月对患者进行膀胱镜检查。

结果

平均手术时间为40分钟。1例因复发性梗阻接受了再次手术,1例双侧POM患者因5级膀胱输尿管反流接受了科恩(Cohen)再植手术。其他11例患者的肾积水有所改善,输尿管直径较术前测量值明显减小。膀胱镜检查时,发现输尿管口呈粗大的火山状,尿液间歇性喷出。

结论

所提出的婴儿POM“改良输尿管原位再植术”,不进行输尿管变细或推进,是一种简单、可行且侵入性较小的手术,在这个小系列研究中成功率良好。此外,需要更大规模的研究来支持或否定该技术的实用性。

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本文引用的文献

1
'Mini reimplantation' for the management of primary obstructed megaureter.用于原发性梗阻性巨输尿管治疗的“微型再植术”
J Pediatr Urol. 2016 Apr;12(2):103.e1-4. doi: 10.1016/j.jpurol.2015.08.017. Epub 2015 Oct 8.
2
Intravesical tunnel length to ureteral diameter ratio insufficiently explains ureterovesical junction competence: A parametric simulation study.膀胱内隧道长度与输尿管直径之比不足以解释输尿管膀胱连接部的功能:一项参数模拟研究。
J Pediatr Urol. 2015 Jun;11(3):144.e1-5. doi: 10.1016/j.jpurol.2015.01.015. Epub 2015 Mar 13.
3
Refluxing ureteral reimplantation: a logical method for managing neonatal UVJ obstruction.
反流性输尿管再植术:一种治疗新生儿输尿管膀胱连接部梗阻的合理方法。
J Pediatr Urol. 2014 Oct;10(5):824-30. doi: 10.1016/j.jpurol.2014.01.027. Epub 2014 Feb 28.
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British Association of Paediatric Urologists consensus statement on the management of the primary obstructive megaureter.英国小儿泌尿外科医师协会关于原发性梗阻性巨输尿管管理的共识声明。
J Pediatr Urol. 2014 Feb;10(1):26-33. doi: 10.1016/j.jpurol.2013.09.018. Epub 2013 Oct 16.
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Long-term followup of primary nonrefluxing megaureter.原发性非反流巨输尿管的长期随访。
J Urol. 2013 Sep;190(3):1021-6. doi: 10.1016/j.juro.2013.03.008. Epub 2013 Mar 7.
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Resolution of primary non-refluxing megaureter: an observational study.原发性非反流性巨输尿管的缓解:一项观察性研究。
J Pediatr Surg. 2013 Feb;48(2):380-3. doi: 10.1016/j.jpedsurg.2012.11.017.
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Vesicoureteral reflux: current trends in diagnosis, screening, and treatment.膀胱输尿管反流:诊断、筛查和治疗的当前趋势。
Eur Urol. 2012 Apr;61(4):773-82. doi: 10.1016/j.eururo.2012.01.002. Epub 2012 Jan 11.
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The utilization of stents in the management of primary obstructive megaureters requiring intervention before 1 year of age.在需要在 1 岁之前进行干预的原发性梗阻性巨输尿管症的管理中使用支架。
J Pediatr Urol. 2011 Apr;7(2):198-202. doi: 10.1016/j.jpurol.2010.04.015. Epub 2010 May 21.
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Pediatr Nephrol. 2010 Sep;25(9):1679-86. doi: 10.1007/s00467-010-1523-0. Epub 2010 Apr 28.
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