Govostis D M, Bandyk D F, Bergamini T M, Towne J B
Surgical Service, Veterans Administration Medical Center, Milwaukee, WI.
Arch Surg. 1989 Apr;124(4):490-3. doi: 10.1001/archsurg.1989.01410040100023.
The influence of venous patching on luminal prostacyclin (PGI2) and thromboxane A2 (TBX) production of endarterectomized arteries was studied in a canine model. Fifteen dogs underwent bilateral common carotid endarterectomies. In each dog, one artery was closed primarily and the contralateral artery was closed by vein-patch angioplasty. At six and 12 weeks after operation, luminal prostanoid production from the venous patch, adjacent endarterectomized artery, and control artery and vein was measured by radioimmunoassay for 6-keto-prostaglandin F1 alpha and thromboxane B2. Venous patches underwent "incomplete" biochemical adaptation with decreased luminal production of PGI2 compared with control and endarterectomized arteries. Thromboxane production from venous patches was increased compared with normal vein but similar to control and endarterectomized arteries. At six weeks, PGI2 production of vein-patched arterial segments was increased compared with arteries closed primarily. These data indicate that vein-patch angioplasty favorably influences surface thrombogenicity of healing, endarterectomized arteries and support its use in reparative carotid surgery.
在犬类模型中研究了静脉补片对动脉内膜切除术后动脉腔内前列环素（PGI2）和血栓素A2（TBX）生成的影响。15只犬接受了双侧颈总动脉内膜切除术。在每只犬中，一侧动脉直接缝合，对侧动脉采用静脉补片血管成形术进行缝合。术后6周和12周，通过放射免疫分析法检测静脉补片、相邻动脉内膜切除术后动脉以及对照动脉和静脉中的腔内前列腺素生成情况，检测指标为6-酮-前列腺素F1α和血栓素B2。与对照动脉和动脉内膜切除术后动脉相比，静脉补片发生了“不完全”生化适应，腔内PGI2生成减少。与正常静脉相比，静脉补片的血栓素生成增加，但与对照动脉和动脉内膜切除术后动脉相似。在6周时，与直接缝合的动脉相比，采用静脉补片的动脉段的PGI2生成增加。这些数据表明，静脉补片血管成形术对愈合中的动脉内膜切除术后动脉的表面血栓形成性有有利影响，并支持其在颈动脉修复手术中的应用。
