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乙状窦后入路与经迷路入路切除听神经瘤:一项比较成本效益分析。

Retrosigmoid versus translabyrinthine approach to acoustic neuroma resection: A comparative cost-effectiveness analysis.

作者信息

Semaan Maroun T, Wick Cameron C, Kinder Kimberly J, Stuyt John G, Chota Rebecca L, Megerian Cliff A

机构信息

University Hospitals Ear, Nose, and Throat Institute, Department of Otolaryngology-Head and Neck Surgery, University Hospitals Case Medical Center, Cleveland, Ohio, U.S.A.

Case Western University School of Medicine, Cleveland, Ohio, U.S.A.

出版信息

Laryngoscope. 2016 Feb;126 Suppl 3:S5-12. doi: 10.1002/lary.25729. Epub 2015 Oct 22.

Abstract

OBJECTIVES/HYPOTHESIS: Approach-specific economic data of acoustic neuroma (AN) resection is lacking. The purpose of this study was to analyze and compare adjusted total hospital costs, hospital and intensive care unit (ICU) length of stay (LOS), and associated factors in AN patients undergoing resection by translabyrinthine (TL) approach versus retrosigmoid (RS) approach.

STUDY DESIGN

Retrospective chart review.

METHODS

A total of 113 patients with AN undergoing TL (N = 43) or RS (N = 70) surgical resection between 1999 and 2012 were analyzed. Data including age, health status, preoperative hearing, tumor size, postoperative complications, hospital, ICU LOS, and disposition after discharge were collected from medical records and compared between both groups. Cost data was obtained from the hospital finance department and adjusted based on the Consumer Price Index for 2013.

RESULTS

There were no significant differences in demographic data, preoperative hearing, preoperative health status, or postoperative complication rate. Total hospital LOS and ICU LOS were significantly longer in the RS compared to the TL group (4.3 ± 3.6 vs. 2.6 ± 1.1 days; P < 0.001, and 1.5 ± 1.1 vs. 1.0 ± 0.5 days; P = 0.015, respectively). Tumors were larger in RS compared to the TL group (2.1 ± 1.0 cm vs. 1.5 ± 0.7 cm, respectively; P = 0.002). When patients were stratified by tumor size < or ≥ 2 cm, the total hospital LOS remained greater in the RS group in both subgroups (< and ≥ 2 cm, P < 0.001, and P = 0.031, respectively). However, there was no difference in the total ICU LOS between both subgroups. The adjusted mean total hospital cost was higher in the RS compared to the TL group ($25,069 ± 14,968 vs. $16,799 ± 5,724; P < 0.001). The adjusted mean total hospital cost was greater in the RS group with tumor < 2 cm (P < 0.001) but not significantly different in patients with tumors ≥ 2 cm. Univariate analysis showed that greater tumor size, poorer preoperative health status, the presence of major postoperative complications, and the RS approach were independently significantly associated with higher total hospital LOS (P = 0.001, P = 0.009, P = 0.001, and P < 0.001, respectively) and a higher adjusted total hospital cost (P < 0.001, P = 0.002, P = 0.014, and P < 0.001, respectively).

CONCLUSION

Hospital LOS and total adjusted costs are significantly less for patients undergoing translabyrinthine acoustic neuroma resection compared to the retrosigmoid approach. Many factors appear to influence these differences. Economic considerations in addition to tumor characteristics and surgeon preference should be considered in future acoustic neuroma resections.

LEVEL OF EVIDENCE

2c.

摘要

目的/假设:目前缺乏听神经瘤(AN)切除术特定手术方式的经济数据。本研究的目的是分析和比较经迷路(TL)入路与乙状窦后(RS)入路切除听神经瘤患者的调整后总住院费用、住院时间和重症监护病房(ICU)住院时间以及相关因素。

研究设计

回顾性病历审查。

方法

分析了1999年至2012年间共113例行TL(N = 43)或RS(N = 70)手术切除的听神经瘤患者。从病历中收集包括年龄、健康状况、术前听力、肿瘤大小、术后并发症、住院时间、ICU住院时间以及出院后去向等数据,并在两组之间进行比较。费用数据从医院财务部门获取,并根据2013年消费者价格指数进行调整。

结果

两组在人口统计学数据、术前听力、术前健康状况或术后并发症发生率方面无显著差异。RS组的总住院时间和ICU住院时间均显著长于TL组(分别为4.3±3.6天对2.6±1.1天;P < 0.001,以及1.5±1.1天对1.0±0.5天;P = 0.015)。RS组的肿瘤比TL组更大(分别为2.1±1.0 cm对1.5±0.7 cm;P = 0.002)。当根据肿瘤大小<或≥2 cm对患者进行分层时,RS组在两个亚组中的总住院时间均更长(<2 cm和≥2 cm亚组,分别为P < 0.001和P = 0.031)。然而,两个亚组之间的ICU总住院时间无差异。RS组的调整后平均总住院费用高于TL组(25,069±14,968美元对16,799±5,724美元;P < 0.001)。肿瘤<2 cm的RS组调整后平均总住院费用更高(P < 0.001),但肿瘤≥2 cm的患者差异不显著。单因素分析显示,肿瘤较大、术前健康状况较差、存在重大术后并发症以及RS入路与总住院时间延长(分别为P = 0.001、P = 0.009、P = 0.001和P < 0.001)和调整后总住院费用增加(分别为P < 0.001、P = 0.002、P = 0.014和P < 0.001)独立显著相关。

结论

与乙状窦后入路相比,经迷路听神经瘤切除术患者的住院时间和总调整费用显著更低。许多因素似乎影响了这些差异。未来听神经瘤切除术应考虑除肿瘤特征和外科医生偏好外的经济因素。

证据级别

2c。

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