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1
The 2-oxo acid dehydrogenase complexes: recent advances.2-氧代酸脱氢酶复合物：最新进展
Biochem J. 1989 Feb 1;257(3):625-32. doi: 10.1042/bj2570625.
2
2-Oxo acid dehydrogenase multienzyme complexes: domains, dynamics, and design.2-氧代酸脱氢酶多酶复合物：结构域、动力学与设计
Ann N Y Acad Sci. 1989;573:1-20. doi: 10.1111/j.1749-6632.1989.tb14983.x.
3
2-Oxo acid dehydrogenase complexes of multicellular organisms.多细胞生物的2-氧代酸脱氢酶复合物
Eur J Biochem. 2003 Mar;270(6):1035. doi: 10.1046/j.1432-1033.2003.03467.x.
4
Structure, function and an inherited defect of 2-oxo acid dehydrogenase multienzyme complexes.2-氧代酸脱氢酶多酶复合物的结构、功能及一种遗传性缺陷
Biochem Soc Trans. 1981 Feb;9(1):6-7. doi: 10.1042/bst0090006.
5
A direct spectrophotometric assay for branched-chain 2-oxo acid dehydrogenase activity in intact rat liver mitochondria.完整大鼠肝线粒体中支链2-氧代酸脱氢酶活性的直接分光光度测定法。
Biochem Soc Trans. 1981 Feb;9(1):117-8. doi: 10.1042/bst0090117.
6
Lipoate addition to acyltransferases of alpha-keto acid dehydrogenase complexes and H-protein of glycine cleavage system.硫辛酸添加到α-酮酸脱氢酶复合物的酰基转移酶和甘氨酸裂解系统的H蛋白上。
Methods Enzymol. 1997;279:184-93. doi: 10.1016/s0076-6879(97)79022-0.
7
Regulation of the alpha-keto acid dehydrogenase complexes and their involvement in primary biliary cirrhosis.α-酮酸脱氢酶复合物的调节及其在原发性胆汁性肝硬化中的作用
Ann N Y Acad Sci. 1989;573:183-91. doi: 10.1111/j.1749-6632.1989.tb14996.x.
8
Uncertainties in the mechanism of thiamin pyrophosphate-dependent alpha-keto acid dehydrogenase complexes.硫胺素焦磷酸依赖性α-酮酸脱氢酶复合体作用机制中的不确定性
Nutr Rev. 1984 Sep;42(9):328-30. doi: 10.1111/j.1753-4887.1984.tb02380.x.
9
Analysis of phosphorylation sites on branched-chain 2-keto acid dehydrogenase complex.支链2-酮酸脱氢酶复合物磷酸化位点的分析
Methods Enzymol. 1988;166:10-4. doi: 10.1016/s0076-6879(88)66004-6.
10
Targeting of 2-oxo acid dehydrogenase complexes to the mitochondrion.将2-氧代酸脱氢酶复合物靶向运输至线粒体。
Ann N Y Acad Sci. 1989;573:254-66. doi: 10.1111/j.1749-6632.1989.tb15002.x.

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Thiamine-responsive maple syrup urine disease missed by newborn screen: A case report.新生儿筛查漏诊的硫胺素反应性枫糖尿症：一例报告
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The branched-chain amino acid-related isoleucic acid: recent research advances.支链氨基酸相关的异亮氨酸：最新研究进展
Plant Biol (Stuttg). 2025 Mar;27(2):195-202. doi: 10.1111/plb.13771. Epub 2025 Jan 22.
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Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production.支链氨基酸：理化性质、工业合成及其在信号转导、代谢和能量产生中的作用。
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Mitochondrial Alpha-Keto Acid Dehydrogenase Complexes: Recent Developments on Structure and Function in Health and Disease.线粒体 α-酮酸脱氢酶复合物：在健康和疾病中的结构和功能的最新进展。
Subcell Biochem. 2024;104:295-381. doi: 10.1007/978-3-031-58843-3_13.
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Cellular metabolism regulates the differentiation and function of T-cell subsets.细胞代谢调节 T 细胞亚群的分化和功能。
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Transcriptome analysis of during intracellular infection reveals excludons are involved with the activation of a mitochondrion-like energy generation program.细胞内感染过程中转录组分析揭示了外显子与类似线粒体的能量生成程序的激活有关。
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A computational model of Pseudomonas syringae metabolism unveils a role for branched-chain amino acids in Arabidopsis leaf colonization.一个拟南芥叶定殖中支链氨基酸作用的丁香假单胞菌代谢的计算模型。
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Neither too much nor too little: mitochondrial calcium concentration as a balance between physiological and pathological conditions.不多不少：线粒体钙浓度作为生理和病理状态之间的平衡。
Front Mol Biosci. 2023 Dec 12;10:1336416. doi: 10.3389/fmolb.2023.1336416. eCollection 2023.
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Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase.结构和生化研究选定的致病性突变体的人二氢硫辛酸脱氢酶。
Int J Mol Sci. 2023 Jun 28;24(13):10826. doi: 10.3390/ijms241310826.
10
Lipoamide dehydrogenase (LADH) deficiency: medical perspectives of the structural and functional characterization of LADH and its pathogenic variants.硫辛酰胺脱氢酶（LADH）缺乏症：LADH 的结构和功能特征及其致病变异体的医学观点。
Biol Futur. 2023 Jun;74(1-2):109-118. doi: 10.1007/s42977-023-00155-6. Epub 2023 Feb 26.

本文引用的文献

1
Mitochondrial presequences.线粒体前序列
J Biol Chem. 1988 Apr 5;263(10):4509-11.
2
Studies on the activation and inactivation of the branched chain alpha-keto acid dehydrogenase in the perfused rat heart.灌注大鼠心脏中支链α-酮酸脱氢酶激活与失活的研究。
J Biol Chem. 1980 Oct 25;255(20):9773-81.
3
Thermolabile factor accelerates pyruvate dehydrogenase kinase reaction in heart mitochondria of starved or alloxan-diabetic rats.热不稳定因子可加速饥饿或四氧嘧啶糖尿病大鼠心脏线粒体中丙酮酸脱氢酶激酶反应。
FEBS Lett. 1981 May 18;127(2):188-92. doi: 10.1016/0014-5793(81)80201-3.
4
Regulation of bovine kidney alpha-ketoglutarate dehydrogenase complex by calcium ion and adenine nucleotides. Effects on S0.5 for alpha-ketoglutarate.钙离子和腺嘌呤核苷酸对牛肾α-酮戊二酸脱氢酶复合体的调节作用。对α-酮戊二酸S0.5的影响。
Biochemistry. 1981 Apr 28;20(9):2512-8. doi: 10.1021/bi00512a023.
5
Inhibition of branched chain alpha-ketoacid dehydrogenase kinase activity by alpha-chloroisocaproate.α-氯异己酸对支链α-酮酸脱氢酶激酶活性的抑制作用。
J Biol Chem. 1982 Dec 10;257(23):13915-8.
6
Pyruvate dehydrogenase kinase/activator in rat heart mitochondria, Assay, effect of starvation, and effect of protein-synthesis inhibitors of starvation.大鼠心脏线粒体中的丙酮酸脱氢酶激酶/激活剂：测定、饥饿的影响以及蛋白质合成抑制剂对饥饿的影响
Biochem J. 1982 Jul 15;206(1):103-11. doi: 10.1042/bj2060103.
7
Mobility of polypeptide chain in the pyruvate dehydrogenase complex revealed by proton NMR.通过质子核磁共振揭示丙酮酸脱氢酶复合体中多肽链的流动性。
Nature. 1981 Jul 30;292(5822):474-7. doi: 10.1038/292474a0.
8
Regulation of the branched chain 2-oxoacid dehydrogenase kinase reaction.支链2-氧代酸脱氢酶激酶反应的调节
FEBS Lett. 1982 Jul 19;144(1):57-62. doi: 10.1016/0014-5793(82)80568-1.
9
Activity state of the branched chain alpha-ketoacid dehydrogenase complex in heart, liver, and kidney of normal, fasted, diabetic, and protein-starved rats.正常、禁食、糖尿病及蛋白质缺乏大鼠心脏、肝脏和肾脏中支链α-酮酸脱氢酶复合体的活性状态
Biochem Biophys Res Commun. 1983 Feb 28;111(1):74-81. doi: 10.1016/s0006-291x(83)80119-3.
10
Subunit structure of dihydrolipoyl transacetylase component of pyruvate dehydrogenase complex from bovine heart.牛心丙酮酸脱氢酶复合体中二氢硫辛酰胺转乙酰酶组分的亚基结构
J Biol Chem. 1981 Jan 10;256(1):514-9.

The 2-oxo acid dehydrogenase complexes: recent advances.

作者信息

Yeaman S J

机构信息

Department of Biochemistry, Medical School, University of Newcastle upon Tyne, U.K.

出版信息

Biochem J. 1989 Feb 1;257(3):625-32. doi: 10.1042/bj2570625.

DOI:10.1042/bj2570625
PMID:2649080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1135633/
Abstract
摘要