Karnaukhov Alexey V, Karnaukhova Elena V, Sergievich Larisa A, Karnaukhova Natalia A, Bogdanenko Elena V, Manokhina Irina A, Karnaukhov Valery N
Institute of Cell Biophysics, Russian Academy of Sciences, Institutskaya Street 3, Pushchino, Moscow 142290, Russia.
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Baltiyskaya Street 8, Moscow 125315, Russia.
J Biophys. 2015;2015:686249. doi: 10.1155/2015/686249. Epub 2015 Sep 30.
The method of lifespan extension that is a practical application of the informational theory of aging is proposed. In this theory, the degradation (error accumulation) of the genetic information in cells is considered a main cause of aging. According to it, our method is based on the transplantation of genetically identical (or similar) stem cells with the lower number of genomic errors to the old recipients. For humans and large mammals, this method can be realized by cryopreservation of their own stem cells, taken in a young age, for the later autologous transplantation in old age. To test this method experimentally, we chose laboratory animals of relatively short lifespan (mouse). Because it is difficult to isolate the required amount of the stem cells (e.g., bone marrow) without significant damage for animals, we used the bone marrow transplantation from sacrificed inbred young donors. It is shown that the lifespan extension of recipients depends on level of their genetic similarity (syngeneity) with donors. We have achieved the lifespan increase of the experimental mice by 34% when the transplantation of the bone marrow with high level of genetic similarity was used.
提出了一种作为衰老信息理论实际应用的寿命延长方法。在该理论中，细胞中遗传信息的降解（错误积累）被认为是衰老的主要原因。据此，我们的方法基于将基因组错误数量较少的基因相同（或相似）干细胞移植到老年受体中。对于人类和大型哺乳动物，这种方法可以通过冷冻保存其年轻时采集的自身干细胞，以供老年时进行自体移植来实现。为了通过实验测试这种方法，我们选择了寿命相对较短的实验动物（小鼠）。由于在不对动物造成重大损害的情况下很难分离出所需数量的干细胞（例如骨髓），我们使用了来自牺牲的近交系年轻供体的骨髓移植。结果表明，受体的寿命延长取决于它们与供体的遗传相似性（同基因性）水平。当使用遗传相似性水平高的骨髓进行移植时，我们使实验小鼠的寿命延长了34%。
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