特应性皮炎中的皮肤微生物群及其与润肤剂的关系。
The Skin Microbiome in Atopic Dermatitis and Its Relationship to Emollients.
作者信息
Lynde Charles W, Andriessen Anneke, Bertucci Vince, McCuaig Catherine, Skotnicki Sandy, Weinstein Miriam, Wiseman Marni, Zip Catherine
机构信息
University of Toronto, Toronto, ON, Canada
Andriessen Consultants Malden and UMC St Radboud Nijmegen, Malden, The Netherlands.
出版信息
J Cutan Med Surg. 2016 Jan;20(1):21-8. doi: 10.1177/1203475415605498. Epub 2015 Oct 22.
BACKGROUND
Human-associated bacterial communities on the skin, skin microbiome, likely play a central role in development of immunity and protection from pathogens. In atopic patients, the skin bacterial diversity is smaller than in healthy subjects.
OBJECTIVE
To review treatment strategies for atopic dermatitis in Canada, taking the skin microbiome concept into account.
METHODS
An expert panel of 8 Canadian dermatologists explored the role of skin microbiome in clinical dermatology, specifically looking at atopic dermatitis.
RESULTS
The panel reached consensus on the following: (1) In atopic patients, the skin microbiome of lesional atopic skin is different from nonlesional skin in adjacent areas. (2) Worsening atopic dermatitis and smaller bacterial diversity are strongly associated. (3) Application of emollients containing antioxidant and antibacterial components may increase microbiome diversity in atopic skin.
CONCLUSION
The skin microbiome may be the next frontier in preventive health and may impact the approach to atopic dermatitis treatment.
背景
人体皮肤上与人类相关的细菌群落，即皮肤微生物群，可能在免疫发育和抵御病原体方面发挥核心作用。在特应性患者中，皮肤细菌多样性低于健康受试者。
目的
考虑皮肤微生物群概念，综述加拿大特应性皮炎的治疗策略。
方法
由8名加拿大皮肤科医生组成的专家小组探讨了皮肤微生物群在临床皮肤病学中的作用，特别是针对特应性皮炎。
结果
专家小组就以下内容达成共识：（1）在特应性患者中，病变部位的特应性皮肤微生物群与相邻部位的非病变皮肤不同。（2）特应性皮炎加重与细菌多样性降低密切相关。（3）应用含有抗氧化和抗菌成分的润肤剂可能会增加特应性皮肤的微生物群多样性。
结论
皮肤微生物群可能是预防保健的下一个前沿领域，并可能影响特应性皮炎的治疗方法。
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