西门子microPET Focus 220临床前扫描仪中Zr-89正电子发射断层显像（PET）成像的图像质量
Image quality of Zr-89 PET imaging in the Siemens microPET Focus 220 preclinical scanner.
作者信息
Bradshaw Tyler J, Voorbach Martin J, Reuter David R, Giamis Anthony M, Mudd Sarah R, Beaver John D
机构信息
Department of Medical Physics, University of Wisconsin, 1111 Highland Ave Rm 1005, Madison, WI, 53705, USA.
Translational Sciences, AbbVie Inc., Bldg. AP4, 1 North Waukegan Road, North Chicago, IL, 60064, USA.
出版信息
Mol Imaging Biol. 2016 Jun;18(3):377-85. doi: 10.1007/s11307-015-0903-z.
PURPOSE
Zr-89 positron emission tomography (PET) is a valuable tool for understanding the biodistribution and pharmacokinetics of antibody-based therapeutics. We compared the image quality of Zr-89 PET and F-18 PET in the Siemens microPET Focus 220 preclinical scanner using different reconstruction methods.
PROCEDURES
Image quality metrics were measured in various Zr-89 and F-18 PET phantoms, including the NEMA NU 4-2008 image quality phantom. Images were reconstructed using various algorithms.
RESULTS
Zr-89 PET had greater image noise, inferior spatial resolution, and greater spillover than F-18 PET, but comparable recovery coefficients for cylinders of various diameters. Of the reconstruction methods, OSEM3D resulted in the lowest noise, highest recovery coefficients, best spatial resolution, but also the greatest spillover. Scatter correction results were found to be sensitive to varying object sizes.
CONCLUSIONS
Zr-89 PET image quality was inferior to that of F-18, and no single reconstruction method was superior in all aspects of image quality.
目的
锆-89正电子发射断层扫描（PET）是了解基于抗体的治疗药物生物分布和药代动力学的重要工具。我们在西门子microPET Focus 220临床前扫描仪中使用不同的重建方法比较了锆-89 PET和氟-18 PET的图像质量。
程序
在各种锆-89和氟-18 PET体模中测量图像质量指标，包括NEMA NU 4-2008图像质量体模。使用各种算法重建图像。
结果
与氟-18 PET相比，锆-89 PET具有更大的图像噪声、较差的空间分辨率和更大的溢出，但对于不同直径的圆柱体，其恢复系数相当。在重建方法中，OSEM3D产生的噪声最低、恢复系数最高、空间分辨率最佳，但溢出也最大。发现散射校正结果对不同的物体大小敏感。
结论
锆-89 PET的图像质量低于氟-18 PET，并且没有一种单一的重建方法在图像质量的所有方面都表现出色。
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