Kleiner Ana, Galli Manuela, Gaglione Maria, Hildebrand Daniela, Sale Patrizio, Albertini Giorgio, Stocchi Fabrizio, De Pandis Maria Francesca
Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milano, Lombardia, Italy ; Movement Analysis and Neuroscience-Neurological Rehabilitation Laboratories, University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, RS, Brazil.
Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milano, Lombardia, Italy ; IRCCS San Raffaele Pisana Tosinvest Sanitá, 00163 Roma, Lazio, Italy.
Parkinsons Dis. 2015;2015:390512. doi: 10.1155/2015/390512. Epub 2015 Oct 1.
This study aims to evaluate the change in gait spatiotemporal parameters in subjects with Parkinson's disease (PD) before and after Automated Mechanical Peripheral Stimulation (AMPS) treatment. Thirty-five subjects with PD and 35 healthy age-matched subjects took part in this study. A dedicated medical device (Gondola) was used to administer the AMPS. All patients with PD were treated in off levodopa phase and their gait performances were evaluated by an inertial measurement system before and after the intervention. The one-way ANOVA for repeated measures was performed to assess the differences between pre- and post-AMPS and the one-way ANOVA to assess the differences between PD patients and the control group. Spearman's correlations assessed the associations between patients with PD clinical status (H&Y) and the percentage of improvement of the gait variables after AMPS (α < 0.05 for all tests). The PD group had an improvement of 14.85% in the stride length; 14.77% in the gait velocity; and 29.91% in the gait propulsion. The correlation results showed that the higher the H&Y classification, the higher the stride length percentage of improvement. The treatment based on AMPS intervention seems to induce a better performance in the gait pattern of PD patients, mainly in intermediate and advanced stages of the condition.
本研究旨在评估帕金森病（PD）患者在接受自动机械外周刺激（AMPS）治疗前后步态时空参数的变化。35例PD患者和35例年龄匹配的健康受试者参与了本研究。使用一种专用医疗设备（吊篮）进行AMPS治疗。所有PD患者均在左旋多巴停药期接受治疗，并在干预前后通过惯性测量系统评估其步态表现。采用重复测量的单因素方差分析来评估AMPS治疗前后的差异，采用单因素方差分析来评估PD患者与对照组之间的差异。Spearman相关性分析评估了PD患者临床状态（H&Y）与AMPS治疗后步态变量改善百分比之间的关联（所有检验α<0.05）。PD组步长改善了14.85%；步态速度改善了14.77%；步态推进力改善了29.91%。相关性结果表明，H&Y分级越高，步长改善百分比越高。基于AMPS干预的治疗似乎能使PD患者的步态模式表现更好，主要是在病情的中晚期。
