腹膜成纤维细胞生物学的新进展：对腹膜透析中炎症和纤维化的影响
New developments in peritoneal fibroblast biology: implications for inflammation and fibrosis in peritoneal dialysis.
作者信息
Witowski Janusz, Kawka Edyta, Rudolf Andras, Jörres Achim
机构信息
Department of Pathophysiology, Poznan University of Medical Sciences, Medical Biology Centre, Rokietnicka 8, 60-806 Poznan, Poland ; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.
Department of Pathophysiology, Poznan University of Medical Sciences, Medical Biology Centre, Rokietnicka 8, 60-806 Poznan, Poland.
出版信息
Biomed Res Int. 2015;2015:134708. doi: 10.1155/2015/134708. Epub 2015 Oct 1.
Uraemia and long-term peritoneal dialysis (PD) can lead to fibrotic thickening of the peritoneal membrane, which may limit its dialytic function. Peritoneal fibrosis is associated with the appearance of myofibroblasts and expansion of extracellular matrix. The extent of contribution of resident peritoneal fibroblasts to these changes is a matter of debate. Recent studies point to a significant heterogeneity and complexity of the peritoneal fibroblast population. Here, we review recent developments in peritoneal fibroblast biology and summarize the current knowledge on the involvement of peritoneal fibroblasts in peritoneal inflammation and fibrosis.
尿毒症和长期腹膜透析（PD）可导致腹膜纤维化增厚，这可能会限制其透析功能。腹膜纤维化与肌成纤维细胞的出现和细胞外基质的扩张有关。腹膜常驻成纤维细胞对这些变化的贡献程度存在争议。最近的研究指出腹膜成纤维细胞群体具有显著的异质性和复杂性。在此，我们综述了腹膜成纤维细胞生物学的最新进展，并总结了目前关于腹膜成纤维细胞参与腹膜炎症和纤维化的知识。
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