巨噬细胞在脑动静脉畸形发病机制中的作用
The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation.
作者信息
Ma Li, Guo Yi, Zhao Yuan-Li, Su Hua
机构信息
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America ; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America ; Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, China.
出版信息
Int J Hematol Res. 2015 Jan 1;1(2):52-56. doi: 10.17554/j.issn.2409-3548.2015.01.12. Epub 2015 Jul 6.
Brain arteriovenous malformation (BAVM) is an important risk factor for intracranial hemorrhage, especially in children and young adults. Inflammation has been implicated in BAVM lesion progression. Among various inflammatory components, macrophage is one of the major inflammatory cells present in human ruptured and unruptured BAVM and in the BAVM lesions of animal models. The role of macrophage in BAVM pathogenesis is not fully understood. In this review, we summarize recent studies on macrophages and introduce a non-invasive imaging protocol as a potential tool for detecting macrophage in BAVM and predicting the risk of BAVM rupture.
脑动静脉畸形（BAVM）是颅内出血的一个重要危险因素，尤其是在儿童和年轻人中。炎症与BAVM病变进展有关。在各种炎症成分中，巨噬细胞是人类破裂和未破裂的BAVM以及动物模型的BAVM病变中存在的主要炎症细胞之一。巨噬细胞在BAVM发病机制中的作用尚未完全了解。在本综述中，我们总结了关于巨噬细胞的最新研究，并介绍了一种非侵入性成像方案，作为检测BAVM中巨噬细胞和预测BAVM破裂风险的潜在工具。
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