Rushton D N, Brindley G S, Polkey C E, Browning G V
Medical Research Council Neurological Prostheses Unit, London, UK.
J Neurol Neurosurg Psychiatry. 1989 Feb;52(2):223-9. doi: 10.1136/jnnp.52.2.223.
A method is described for coating silicone rubber-encapsulated implant devices with an outer layer of silicone rubber impregnated with a mixture of gentamicin sulphate and diethanolamine fusidate. A coating of this sort provides bactericidal activity lasting for a few days in the film of fluid surrounding such an implant. When used for coating our implants, the retrospective rate of implant infections believed to have been introduced at the time of surgery was reduced to 0.7% (coated), compared with 10.0% (uncoated), a highly significant difference (p less than 0.001). Systemic perioperative antibiotic prophylaxis was not shown to confer any such benefit.
描述了一种用浸渍有硫酸庆大霉素和夫西地酸二乙醇胺混合物的硅橡胶外层涂覆硅橡胶封装植入装置的方法。这种涂层在围绕此类植入物的流体薄膜中提供持续数天的杀菌活性。当用于涂覆我们的植入物时，据信在手术时引入的植入物感染的回顾性发生率降至0.7%（涂覆），而未涂覆时为10.0%，差异非常显著（p小于0.001）。未显示围手术期全身抗生素预防有任何此类益处。
