Ksander G A, Gray L
Ann Plast Surg. 1985 Apr;14(4):351-60. doi: 10.1097/00000637-198504000-00009.
Silicone rubber miniprostheses were coated with solid collagen formed from a fibrillar collagen suspension (Zyderm collagen implant) and then implanted subcutaneously in rats. There was a reduced amount of capsule formation around the coated prostheses, whereas the uncoated control implants all became surrounded by normal capsule. At the interface between the collagen coating and the surrounding tissue, no capsule formation was seen. At the interface between the prosthesis and the collagen coating, no capsule or only slight, locally limited, capsule formation was seen. Furthermore, capsule associated with coated implants was measurably thinner than that around control implants. When capsule appeared around coated implants, it was frequently associated with defects in the continuity of the coating. Host cells, fibroblasts, and round cells progressively invaded the coatings from the periphery inward, frequently along defects in the coating. The difference between coated and control implants became less pronounced between 60 and 120 days after implantation, as the amount of intact coating decreased. This work supports the hypotheses that the collagen coatings, while intact, prevent capsule formation, that the coatings produced by the present method are imperfect and are broken down with time, and that the disappearance of the coatings results in subsequent capsule formation. These hypotheses permit the deduction that development of better, more persistent coatings will permit indefinitely prolonged inhibition of capsule formation.
将硅橡胶微型假体用由纤维状胶原悬浮液形成的固态胶原（Zy derm胶原植入物）包被，然后皮下植入大鼠体内。包被的假体周围形成的包膜量减少，而未包被的对照植入物均被正常包膜所包围。在胶原包被与周围组织的界面处，未见包膜形成。在假体与胶原包被的界面处，未见包膜形成或仅见轻微的、局部受限的包膜形成。此外，与包被植入物相关的包膜明显比对照植入物周围的包膜薄。当包被植入物周围出现包膜时，它常与包被的连续性缺陷有关。宿主细胞、成纤维细胞和圆形细胞从周边向内部逐渐侵入包被，常沿着包被中的缺陷侵入。植入后60至120天之间，由于完整包被量减少，包被植入物与对照植入物之间的差异变得不那么明显。这项工作支持以下假设：胶原包被在完整时可防止包膜形成；本方法产生的包被不完美且会随时间分解；包被的消失导致随后的包膜形成。这些假设可以推断出，开发更好、更持久的包被将能够无限期地延长对包膜形成的抑制作用。
