肉芽肿性多血管炎的耳病理学
Otopathology of Vasculitis in Granulomatosis With Polyangitis.
作者信息
Santos Felipe, Salviz Mehti, Domond Haris, Nadol Joseph B
机构信息
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary; and Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, U.S.A.
出版信息
Otol Neurotol. 2015 Dec;36(10):1657-62. doi: 10.1097/MAO.0000000000000868.
OBJECTIVE
To describe the temporal bone histopathology of vasculitis in granulomatosis with polyangitis.
BACKGROUND
Granulomatosis with polyangitis is an autoimmune disease that presents as granulomatosis and vasculitis. Otologic findings, including otitis media, hearing loss, vertigo, and facial paralysis are common in this condition.
MATERIAL AND METHODS
The temporal bones of four subjects with manifestations of vasculitis attributed to granulomatosis with polyangitis were studied under light microscopy.
RESULTS
The four subjects had manifestations of vasculitis including hemorrhage within the cochlea and vestibule, and inflammation and occlusion of vessels in the lateral cochlear wall and the vasa nervorum of the facial nerve.
CONCLUSIONS
We infer that sensorineural hearing loss, vestibulopathy, and facial nerve paresis in granulomatosis with polyangitis can be the results of vasculitis.
目的
描述显微镜下多血管炎肉芽肿中血管炎的颞骨组织病理学特征。
背景
显微镜下多血管炎是一种自身免疫性疾病，表现为肉芽肿和血管炎。耳部症状，包括中耳炎、听力损失、眩晕和面神经麻痹在这种疾病中很常见。
材料与方法
对4例显微镜下多血管炎肉芽肿血管炎表现的患者颞骨进行光学显微镜研究。
结果
4例患者均有血管炎表现，包括耳蜗和前庭内出血，以及耳蜗外侧壁和面神经神经束膜血管的炎症和闭塞。
结论
我们推断显微镜下多血管炎肉芽肿中的感音神经性听力损失、前庭病变和面神经麻痹可能是血管炎的结果。
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