Cuadros Diego F, Miller F DeWolfe, Nagelkerke Nico, Abu-Raddad Laith J
Infectious Disease Epidemiology Group, Weill Cornell Medical College-Qatar, Cornell University, Qatar Foundation-Education City, Doha, Qatar; Department of Healthcare Policy and Research, Weill Cornell Medical College, Cornell University, New York, NY.
Department of Tropical Medicine and Medical Microbiology and Pharmacology, University of Hawaii, Honolulu.
Ann Epidemiol. 2015 Dec;25(12):918-23. doi: 10.1016/j.annepidem.2015.09.005. Epub 2015 Sep 28.
There is a conflicting evidence about the association between hepatitis C virus (HCV) infection and diabetes mellitus. The objective of this study was to assess this association in Egypt, the country with the highest HCV prevalence in the world.
The source of data was from the Egypt Demographic and Health Survey conducted in 2008. Using multivariable logistic regression analyses to account for known confounders, the association was investigated at two levels']: (1) HCV exposure (HCV antibody status) and diabetes mellitus and (2) diabetes mellitus and chronic HCV infection (HCV RNA status) among HCV-exposed individuals.
We found no evidence for an association between HCV antibody status and diabetes (adjusted odds ratio [OR] = 0.87; 95% confidence interval [CI], 0.63-1.19). However, among HCV-exposed individuals, we found an evidence for an association between diabetes and active HCV infection (adjusted OR = 2.44, 95% CI, 1.30-4.57).
Although it does not appear that HCV exposure and diabetes are linked, there might be an association between diabetes and chronic HCV infection. The HCV-diabetes relationship may be more complex than previously anticipated. Therefore, a call for an "amicable divorce" to the HCV-diabetes relationship could be premature.
关于丙型肝炎病毒（HCV）感染与糖尿病之间的关联，存在相互矛盾的证据。本研究的目的是在埃及这个全球HCV患病率最高的国家评估这种关联。
数据来源是2008年进行的埃及人口与健康调查。使用多变量逻辑回归分析来考虑已知的混杂因素，在两个层面上研究这种关联：（1）HCV暴露（HCV抗体状态）与糖尿病；（2）在HCV暴露个体中糖尿病与慢性HCV感染（HCV RNA状态）。
我们没有发现HCV抗体状态与糖尿病之间存在关联的证据（调整后的优势比[OR]=0.87；95%置信区间[CI]，0.63 - 1.19）。然而，在HCV暴露个体中，我们发现糖尿病与活动性HCV感染之间存在关联的证据（调整后的OR = 2.44，95% CI，1.30 - 4.57）。
虽然HCV暴露与糖尿病似乎没有关联，但糖尿病与慢性HCV感染之间可能存在关联。HCV与糖尿病的关系可能比之前预期的更为复杂。因此，呼吁HCV与糖尿病“友好分手”可能为时过早。
